Actively Recruiting

Phase Not Applicable
Age: 18Years - 43Years
FEMALE
ID07119060

Comparison of Pregnancy Rates After Cystectomy, Plasma Vaporization, or Sclerotherapy in Women With Endometriomas

Led by Clinique Tivoli Ducos · Updated on 2026-03-19

332

Participants Needed

1

Research Sites

26 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This trial investigates different surgical methods for treating endometriomas, which are ovarian cysts larger than 2 cm, in adult women aged 18 to 43 who have symptoms like pelvic pain or fertility issues. The study aims to compare pregnancy rates within 24 months after surgery, along with birth rates, types of pregnancies, recurrence of cysts, complications, and changes in pain levels. Researchers seek to find which surgical approach yields better pregnancy outcomes and fewer problems. Participants are randomly assigned to one of three surgical treatments: cystectomy, where the cyst wall is gently removed from the ovary; plasma vaporization, which destroys the cyst wall using plasma energy; or ethanol sclerotherapy, which uses alcohol to destroy the cyst lining. After surgery, women will have follow-up visits at 3 months and 24 months to monitor their recovery and pregnancy progress. During the study, participants will be evaluated through medical imaging, symptom questionnaires, and monitoring of pregnancy outcomes including natural and assisted pregnancies. Researchers will track recurrence of cysts over 24 months and assess pain using a standardized scale. Safety and complications will be recorded during the first 3 months post-surgery. The total participation spans from surgery through two years of follow-up evaluations.

CONDITIONS

Brief Title

Ablative Technique For Ovarian Preservation In Endometrioma

Who Can Participate

Age: 18Years - 43Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient aged between 18 and 43 years (inclusive)
  • Diagnosed with endometriosis by histology or imaging and symptomatic, requiring surgery
  • Pelvic MRI or ultrasound within last year showing at least one endometrioma larger than 20 mm
  • Has intention to conceive after surgery
  • Informed consent signed
  • Covered by a social security scheme
Not Eligible

You will not qualify if you...

  • Cyst found during surgery is not an endometrioma
  • Under guardianship, conservatorship, or incapable of giving consent
  • Insufficient understanding of French language
  • Under judicial protection measures
  • Currently pregnant or breastfeeding

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Surgery and Immediate Post-operative Care

Duration - Surgery day plus 3 months post-operative period

Participants undergo one of three surgical procedures to treat endometriomas: cystectomy, plasma vaporization, or sclerotherapy.

Approximately 6 post-operative visits

Long-term Monitoring

Duration - Up to 24 months after surgery

Participants are monitored for pregnancy rates and endometrioma recurrence following surgery.

Regular follow-up visits during this period

Trial Site Locations

Total: 1 location

1

IFEMEndo - Clinique Tivoli

Bordeaux, France, 33000

Actively Recruiting

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Research Team

C

Clotilde HUET

K

Kristina ANANIAN

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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Published Research Related To This Trial

ATOPE study protocol: a randomised controlled trial comparing cystectomy and plasma vapourisation in endometriomas under 6 cm, with an observational arm for sclerotherapy in larger cysts.

Adrien Crestani, Benjamin Merlot, Isabella Chanavaz Lacheray...

https://pubmed.ncbi.nlm.nih.gov/42049313