Comparison of Pregnancy Outcomes After Different Surgeries for Endometriomas in Women Aged 18 to 43
Led by Clinique Tivoli Ducos · Updated on 2026-03-19
332
Participants Needed
1
Research Sites
26 weeks
Total Duration
AI-Summary
What this Trial Is About
This trial investigates different surgical methods for treating endometriomas, which are ovarian cysts larger than 2 cm, in adult women aged 18 to 43 who have symptoms like pelvic pain or fertility issues. The study aims to compare pregnancy rates within 24 months after surgery, along with birth rates, types of pregnancies, recurrence of cysts, complications, and changes in pain levels. Researchers seek to find which surgical approach yields better pregnancy outcomes and fewer problems.
Participants are randomly assigned to one of three surgical treatments cystectomy, where the cyst wall is gently removed from the ovary plasma vaporization, which destroys the cyst wall using plasma energy or ethanol sclerotherapy, which uses alcohol to destroy the cyst lining. After surgery, women will have follow-up visits at 3 months and 24 months to monitor their recovery and pregnancy progress.
During the study, participants will be evaluated through medical imaging, symptom questionnaires, and monitoring of pregnancy outcomes including natural and assisted pregnancies. Researchers will track recurrence of cysts over 24 months and assess pain using a standardized scale. Safety and complications will be recorded during the first 3 months post-surgery. The total participation spans from surgery through two years of follow-up evaluations.
CONDITIONS
Brief Title
Ablative Technique For Ovarian Preservation In Endometrioma
Research Team
C
Clotilde HUET
K
Kristina ANANIAN
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Diagnosed with endometriosis by histology or imaging and symptomatic, requiring surgery
Pelvic MRI or ultrasound within last year showing at least one endometrioma larger than 20 mm
Has intention to conceive after surgery
Informed consent signed
Covered by a social security scheme
You will not qualify if you...
Cyst found during surgery is not an endometrioma
Under guardianship, conservatorship, or incapable of giving consent
Insufficient understanding of French language
Under judicial protection measures
Currently pregnant or breastfeeding
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Surgery and Immediate Post-operative Care
Duration - Surgery day plus 3 months post-operative period
Participants undergo one of three surgical procedures to treat endometriomas: cystectomy, plasma vaporization, or sclerotherapy.
Approximately 6 post-operative visits
Long-term Monitoring
Duration - Up to 24 months after surgery
Participants are monitored for pregnancy rates and endometrioma recurrence following surgery.
Regular follow-up visits during this period
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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Published Research Related To This Trial
ATOPE study protocol: a randomised controlled trial comparing cystectomy and plasma vapourisation in endometriomas under 6 cm, with an observational arm for sclerotherapy in larger cysts.
Adrien Crestani, Benjamin Merlot, Isabella Chanavaz Lacheray...