Actively Recruiting
Absorbed Tumor Dose in Peptide Receptor Radionuclide Therapy with Long-acting Somatostatin Analogues - ATSA Trial
Led by The Netherlands Cancer Institute · Updated on 2025-03-03
39
Participants Needed
1
Research Sites
139 weeks
Total Duration
On this page
Sponsors
T
The Netherlands Cancer Institute
Lead Sponsor
N
Neuroendocrine Tumor Research Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
According to current guidelines, patients have to withhalt long-acting somatostatin analogues (LA-SSA) for 4-6 weeks prior to every 177Lutetium-DOTATATE administration. The primary objective of the study is to investigate the effect of LA-SSA on the absorbed dose in tumor lesions during PRRT.
CONDITIONS
Official Title
Absorbed Tumor Dose in Peptide Receptor Radionuclide Therapy with Long-acting Somatostatin Analogues - ATSA Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 218 years or older
- Able to provide spoken and written informed consent for the trial
- Histopathological confirmed neuroendocrine tumor
- Meet clinical criteria for PRRT
- At least one soft tissue lesion larger than 2 cm
- Planned administered activity of 7400 MBq
- ECOG performance status score between 0 and 2
You will not qualify if you...
- Unable to stop long-acting somatostatin analogue treatment for 4-6 weeks
- Use of short-acting somatostatin analogues
- Pregnancy or currently breastfeeding
- Unable to follow study procedures
- Conditions that could affect drug biodistribution, such as need for furosemide right after PRRT, limited fluid intake, or presence of renal catheters
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Antoni van Leeuwenhoek
Amsterdam, Netherlands
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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