Study of Oral Antibiotic Absorption in Adults with Short Bowel Syndrome Comparing IV and Oral Treatments

What this Trial Is About

Researchers are evaluating how well oral antibiotics are absorbed in patients with short bowel syndrome. This condition can affect how medications are processed in the body. The study aims to compare the absorption of antibiotics given intravenously and then orally to better understand the oral bioavailability in these patients. Each participant will first receive an intravenous antibiotic to treat their infection. After completing this intravenous treatment, they will be given the same antibiotic orally for a few days. The antibiotics studied include amoxicillin, ofloxacin, levofloxacin, and sulfamethoxazoletrimethoprim. This pilot study is being conducted at a single center. During the study, researchers will measure the levels of the antibiotic in the blood at multiple time points before and after oral administration to assess absorption. They will also collect information about the length of the remaining bowel and its relationship with antibiotic absorption. Participants will be monitored closely throughout the treatment periods, and the study will continue until February 2025.

Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome