Actively Recruiting
ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study
Led by University Hospital, Basel, Switzerland · Updated on 2026-05-04
32
Participants Needed
2
Research Sites
80 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.
CONDITIONS
Official Title
ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 60 years
- Written informed consent provided
- Scheduled for routine lumbar puncture (spinal fluid collection)
- For obese participants: Body mass index (BMI) of 30 kg/m2 or higher
- For lean participants: Body mass index (BMI) between 18 and 25 kg/m2
- No diagnosis of diabetes (for obese participants)
You will not qualify if you...
- Allergy to the natural odour
- Acute upper respiratory tract infection or acute/chronic sinusitis
- Past or present surgery of the nasal cavity, paranasal sinus, pituitary, or frontal brain
- Pregnancy or breastfeeding
- Severe chronic diseases such as severe heart failure, active cancer, or severe kidney problems with low filtration rate
- Inability to understand the study and provide informed consent
AI-Screening
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Trial Site Locations
Total: 2 locations
1
University Hospital Basel
Basel, Switzerland, 4031
Not Yet Recruiting
2
University Hospital of Basel
Basel, Switzerland, 4031
Actively Recruiting
Research Team
K
Katharina Timper, Prof. Dr. med.
CONTACT
I
Isabel M Hofer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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