Study of a Natural Odour in Cerebrospinal Fluid After Inhalation in Adults with Overweight or Normal Weight

What this Trial Is About

This research aims to study the presence of a natural odour in the cerebrospinal fluid of both obese and lean adults following inhalation. The trial includes participants who are scheduled for a routine lumbar puncture as part of standard medical care. Researchers want to compare how this odour shows up in the fluid and in the blood before and after exposure, focusing on differences between lean and obese individuals. Participants will be randomly assigned to inhale either 50 microliters of a natural odour or a placebo propylene glycol using a nasal mini-inhaler over 15 minutes. The study is single-blinded, meaning participants do not know which inhaler they receive. Both treatment groups undergo the inhalation procedure before the lumbar puncture. During the study, blood samples will be collected immediately before and within 30 minutes after inhalation. The main measurement is detecting the natural odour in the cerebrospinal fluid at baseline. Researchers will also assess changes in the odours abundance in blood and compare results between obese and lean participants. The trial expects participant involvement around the time of their scheduled lumbar puncture.

ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study