The Effect of Flavor and Nicotine Strength on the Abuse Liability and Appeal of Oral Nicotine Products

What this Trial Is About

Researchers are investigating the appeal and potential for abuse of new oral nicotine products (ONPs), such as gums and pouches, among young adults who currently use e-cigarettes (ECs). This study focuses on how flavor (mint vs. fruit) and nicotine strength (2mg vs. 6mg) influence the attractiveness and abuse risk of these products. Special attention is given to sexual and gender minority (SGM) individuals, as they show higher interest in ONPs. Understanding these factors will help guide regulations to prevent harmful dual use of ECs and ONPs that may increase nicotine dependence. Participants will be randomly assigned to use either nicotine gum or pouches with a low (2mg) or high (6mg) nicotine dose. The study involves three virtual sessions conducted remotely, where participants self-administer different flavored ONPs and provide ratings on appeal and sensory experiences. Following initial sensory testing, participants complete two abuse liability sessions with their preferred mint and fruit flavors, including controlled use and a seven-day period of naturalistic product use at home. Throughout the study, participants will complete surveys on nicotine withdrawal, cravings, and subjective effects. Behavioral economic measures will assess the demand for ONPs under different conditions. Researchers will monitor natural use patterns, including use in places where vaping is usually restricted. The primary outcomes are product appeal and consumption immediately after use, with additional measures taken during and after the abuse liability sessions. Participants will be closely monitored for nicotine abstinence and adherence during each phase of the study.

Abuse Liability and Appeal of Oral Nicotine Products