Actively Recruiting
ABY-029 Glioma Trial
Led by Dartmouth-Hitchcock Medical Center · Updated on 2026-03-10
33
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
Sponsors
D
Dartmouth-Hitchcock Medical Center
Lead Sponsor
D
Dartmouth College
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purposes of the research trial are to study the safety of ABY-029 and to understand how much of the drug is needed to reach brain tumors so it can be visualized best by surgeons. Investigators will do this by comparing two groups of participants that receive different, very small amounts of ABY-029. Investigators will use an imaging system during surgery to record the amount of ABY-029 in the participant's tumor and in the surrounding tissue.
CONDITIONS
Official Title
ABY-029 Glioma Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of presumed high-grade glioma based on imaging data
- Tumor planned for open cranial resection
- Valid informed consent given by participant
- Age 18 years or older
- Ability to understand and willingness to sign informed consent document
You will not qualify if you...
- Prisoners
- Pregnant or breastfeeding individuals
- Participants on any experimental or approved anti-EGFR targeted therapies
- Elevated kidney or liver function tests greater than 2.5 times normal within 30 days before surgery
- Any condition that contraindicates research participation as judged by the clinical investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
Research Team
K
Keith D Paulsen, PhD
CONTACT
L
Linton Evans, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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