Actively Recruiting
Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
Led by Columbia University · Updated on 2026-04-13
144
Participants Needed
1
Research Sites
136 weeks
Total Duration
On this page
Sponsors
C
Columbia University
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive impairment.
CONDITIONS
Official Title
Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed stage 3-4 chronic kidney disease with estimated glomerular filtration rate between less than 60 to 20 ml/min
- Age over 55 years
- Mild cognitive impairment with Montreal Cognitive Assessment (MOCA) score between 18 and 26
- Ability to undergo MRI
- No history of major head trauma or concussion with loss of consciousness
- Ability to speak, read, and write English
You will not qualify if you...
- Diagnosed dementia or Clinical Dementia Rating Scale score of less than 2, or MOCA score less than 18
- Participating in a supervised exercise program aiming to increase fitness three or more days per week
- Requires assistive devices for walking
- Limited exercise capacity due to claudication, unstable angina, severe arthritis, extreme shortness of breath on exertion, or unstable coronary artery disease
- Class III-IV heart failure
- History of uncontrolled arrhythmias, severe/symptomatic heart valve disease, hypertrophic obstructive cardiomyopathy, severe pulmonary hypertension, active myocarditis or pericarditis, thrombophlebitis, or recent embolism
- Resting systolic blood pressure over 200 mmHg or diastolic blood pressure over 110 mmHg
- Any illness or disability preventing cognitive testing or exercise training
- Contraindications for MRI such as cardiac pacemaker, aneurysm clip, cochlear implants, shrapnel, metal fragments in eyes, neurostimulators, or claustrophobia
- Major psychiatric disorders requiring medical treatment, such as schizophrenia or bipolar disorder
- New diagnosis of clinical depression within 3 months or unstable depression requiring medication changes within 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Columbia University
New York, New York, United States, 10023
Actively Recruiting
Research Team
U
Ulf G Bronas, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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