Actively Recruiting
Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population
Led by Ningbo No. 1 Hospital · Updated on 2025-06-04
2720
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The association between biological aging and type 2 diabetes mellitus (T2DM) incidence in individuals with and without metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.We assessed biological age by calculating phenotypic age (PhenoAge), Klemera-Doubal method (KDMAge), and homeostatic dysregulation (HDAge). To examine the association of biological ageing with the risk of T2DM, cox regression models were conducted. Furthermore, we applied survival analysis, restricted cubic spline models and population attributable fraction (PAF) to further evaluate the association between biological ageing and T2DM incidence.
CONDITIONS
Official Title
Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Abdominal ultrasound data available in annual health check-up records
- At least one of the following five metabolic indicators recorded annually: body mass index or waist circumference, blood pressure, serum triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose or glycated hemoglobin (HbA1c)
You will not qualify if you...
- Age younger than 20 years or older than 90 years
- Other causes of hepatic steatosis such as alcoholic liver disease or hepatitis B infection
- Type 2 diabetes mellitus at baseline
- Missing baseline data for systolic blood pressure, albumin, alkaline phosphatase, blood urea nitrogen, creatinine, glycated hemoglobin (HbA1c), total cholesterol, lymphocyte percentage, white blood cell count, mean corpuscular volume, uric acid, fasting plasma glucose, or red cell distribution width (RDW)
AI-Screening
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Trial Site Locations
Total: 1 location
1
the First Affiliated Hospital of Ningbo University Ningbo, Zhejiang, China, 315000
Ningbo, Zhejiang, China, 315000
Actively Recruiting
Research Team
L
Lei Xu
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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