Actively Recruiting
Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk
Led by University of California, Davis · Updated on 2026-03-11
25
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
Sponsors
U
University of California, Davis
Lead Sponsor
S
Sorensen Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if a fast-acting brain stimulation treatment called transcranial magnetic stimulation (TMS) can help people with depression and suicidal thoughts. The treatment is non-invasive (does not involve surgery or medications), is given over 5 days, and uses brain imaging (MRI) to guide which part of the brain to target. This study tests whether this treatment is a helpful and practical option for adolescents and young adults who are depressed and have suicidal thoughts. We want to see if: 1. This treatment is feasible and acceptable to patients 2. It can reduce depression and suicidal thoughts 3. It can lower the chance of going to the hospital 4. It affects daily functioning (school, work, relationships) All participants will undergo 5-days of TMS treatment and complete MRI brain scans before and after treatment. They will return for check-ups after 1 week and 4 weeks.
CONDITIONS
Official Title
Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to speak English
- Able to provide informed consent
- Age between 15 and 25 years
- Discharged within the past week from emergency department for suicidal thoughts, or recently admitted in urgent care or seen in outpatient clinic for depression-related suicidal ideation
- Meets criteria for major depressive disorder per Mini International Neuropsychiatric Interview (MINI)
You will not qualify if you...
- Unable to provide consent due to medical condition, psychosis, substance use, or other reasons
- Use of benzodiazepines or medications that interfere with TMS treatment as determined by the principal investigator
- Active or severe substance use that interferes with study participation
- Untreated, active psychosis
- Female who is breastfeeding, pregnant, or planning pregnancy during the study
- Participation in any clinical study with investigational treatment within the last 30 days or plans to participate in other studies concurrently
- Contraindications to receiving TMS or MRI as determined by screening questionnaires
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UC Davis Medical Center
Sacramento, California, United States, 95817
Actively Recruiting
Research Team
S
Se Ri (Sally) Bae, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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