Brain Stimulation Treatment Using Accelerated Intermittent Theta Burst Stimulation for Depression and Suicidal Thoughts in Adolescents and Young Adults Aged 15 to 25

What this Trial Is About

Researchers are evaluating a fast-acting, non-invasive brain stimulation treatment called transcranial magnetic stimulation TMS in adolescents and young adults aged 15 to 25 who have major depressive disorder and suicidal thoughts. This study aims to see if TMS is feasible, acceptable, and helpful in reducing depression, suicidal thoughts, hospital visits, and improving daily functioning like school, work, and relationships. Participants receive TMS treatment over 5 consecutive days, with ten hourly sessions each day delivering bursts of magnetic pulses to targeted brain areas guided by MRI scans. Each session delivers 60 cycles of bursts at specific frequencies and intensities, totaling 90,000 pulses during the treatment period. MRI brain scans are done before and after the treatment to guide and assess the intervention. During the study, participants will have follow-up visits 1 week and 4 weeks after treatment to monitor changes in depression scores, suicidal ideation, healthcare use, and quality of life. Researchers will measure depression changes primarily using the MADRS score at 1 week. Safety and functioning assessments will also be completed. The total involvement spans from initial MRI and treatment through follow-up evaluations to understand the treatments effects and feasibility.

Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk