Actively Recruiting
Accelerated Intermittent Theta Burst Stimulation (AiTBS)on Neuropathic Pain
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2026-01-26
120
Participants Needed
1
Research Sites
120 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The present study was designed to be the first to evaluate the efficacy of the AiTBS protocol to relieve neuropathic pain in a therapeutic setting, i.e. with repeated stimulation sessions. The investigator directly compared the analgesic efficacy of AiTBS versus conventional 10-Hz rTMS delivered to the left M1. In addition to pain experiences, The investigator examined the effects of intervention on corticospinal excitability that assessed by TMS-EEG. The working hypothesis was that AiTBS would result in larger analgesic and significant cortical excitability changes compared to 10-Hz rTMS. Eligible patients were randomly assigned to receive either 5 days of AiTBS within 10 days (6 sessions per day) or 10 consecutive days of classic 10Hz rTMS intervention. Clinical and neurophysiological assessments were performed at baseline and after the last sessions.
CONDITIONS
Official Title
Accelerated Intermittent Theta Burst Stimulation (AiTBS)on Neuropathic Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of peripheral neuropathic pain by IASP
- Pain lasting at least three months
- Moderate or higher pain intensity (score of 3 or more on VAS or NRS)
- Age 18 years or older
- Stable medical treatment from 2 weeks before enrollment until the end of the trial
- Willingness to receive TMS treatment and ability to complete clinical assessments
You will not qualify if you...
- Contraindications to TMS treatment such as metal implants or seizure history
- Severe psychiatric disorders (Hamilton Depression Rating Scale score 35 or higher or Hamilton Anxiety Rating Scale score 29 or higher)
- Aphasia or cognitive impairment (Mini Mental State Examination score 24 or lower)
- Serious clinical disorders from tumors or other conditions
- Severe heart or lung dysfunction or extreme weakness
- History of substance abuse including alcohol or drugs
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
Actively Recruiting
Research Team
Y
Ying Liu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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