Actively Recruiting
Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway
Led by First Affiliated Hospital of Zhejiang University · Updated on 2023-06-22
90
Participants Needed
1
Research Sites
213 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Major depressive disorder(MDD) is a complex and heterogeneous mental disorder. Repeated transcranial magnetic stimulation (rTMS), as a non-invasive neuroregulatory technique, has shown a promising function in the treatment of depression. Theta-burst transcranial magnetic stimulation (TBS) model significantly shortened the duration of physical therapy treatment, and iTBS under the accelerated model (The latter is referred to as aiTBS)showed promising therapeutic effect. However, whether aiTBS has a better and faster curative effect in the first untreated or recurrent unmedicated MDD patients and the mechanism of its alleviation of depressive symptoms remains unclarified. This project intends to verify changes in CAMKII levels, CAMKII molecules and GABA receptors in brain-derived exosomes in normal controls and patients who received sham, aiTBS and high-frequency (10Hz) stimulation respectively. Neuroimaging and TMS-EEG were used to pinpoint the target of stimulation and to record the changes of brain waves before and after treatment in real time. To clarify the neurobiological mechanism of aiTBS rapidly improving depression, and to provide a new strong evidence for clinical transcranial magnetic stimulation for accurate treatment of MDD patients.
CONDITIONS
Official Title
Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed written informed consent to participate and receive treatment
- Diagnosed with major depressive disorder
- Hamilton Depression Scale (HAMD-24) total score of 20 or more
- First episode or recurrent depression patients not currently taking psychiatric drugs
- Han nationality and right-handed
- Education level of junior high school or above
You will not qualify if you...
- Other organic mental disorders, mental retardation, or severe mental disorders
- Infection, trauma, autoimmune diseases, or other conditions that may affect test evaluations
- Alcohol or drug dependence or current treatment with hormone drugs
- History of craniocerebral injury
- Seizure history or family history of epilepsy
- Pregnant or lactating women
- Presence of metal in the body, MRI contraindications, or abnormal brain structure on MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
the First Affiliated Hospital,Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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