Actively Recruiting
Accelerated iTBS for Depression: Monitoring Brain Hemodynamics With Simultaneous iTBS/fNIRS
Led by The Hong Kong Polytechnic University · Updated on 2025-05-14
1
Participants Needed
1
Research Sites
14 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will investigate the cortical hemodynamic response variability of an accelerated form of TBS stimulation over left dorsolateral prefrontal cortex (DLPFC) using a concurrent TBS/fNIRS setup. The accelerating TMS protocol that will be used in this study is similar to the Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT), i.e., fifty iTBS sessions (1,800 pulses per session, 50-minute intersession interval) will be delivered as 10 daily sessions over 5 consecutive days at 90% resting motor threshold. The investigators will recruit a depressed patient and conduct a concurrent iTBS/fNIRS protocol for each iTBS session. Moreover, the depression symptoms of the patient will be assessed before and after treatment.
CONDITIONS
Official Title
Accelerated iTBS for Depression: Monitoring Brain Hemodynamics With Simultaneous iTBS/fNIRS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 65 years
- Clinical diagnosis of current nonpsychotic major depressive disorder by an experienced psychiatrist according to DSM-IV
- No or stable psychopharmacological medication for at least 2 weeks
- Have not responded to at least one antidepressant medication
- Have not received any TMS treatment
- 17-item Hamilton Depression Rating Scale score of 20 or higher
You will not qualify if you...
- Severe internal diseases
- Neurological disorders or history of severe head injuries
- Having suicidal ideation
- Pregnancy
- History of brain surgery, head injury, cardiac pacemaker, deep brain stimulation, intracranial metallic particles, or history of seizures
- Use of antiepileptics and benzodiazepines equivalent to more than 1 mg lorazepam per day
- Common MRI, fNIRS, and TMS exclusion criteria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Hong Kong Polytechnic University
Hong Kong, Hong Kong
Actively Recruiting
Research Team
G
Georg Kranz, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here