Actively Recruiting
Accelerated iTBS Targeting of Working Memory Versus Inhibitory Control in Adolescent ADHD
Led by Bradley Hospital · Updated on 2025-10-22
50
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this project is to examine the differential therapeutic effect of intermittent theta burst stimulation (iTBS; a type of repetitive transcranial magnetic stimulation) to the left DLPFC versus right PreSMA in modulating working memory (WM) versus inhibitory control (IC) deficits. Fifty adolescents (12-18 years old) with parent-reported WM and IC deficits and diagnosed ADHD will be randomized to DLPFC or PreSMA targeted 3x-daily iTBS for a total of ten days (30 total sessions).
CONDITIONS
Official Title
Accelerated iTBS Targeting of Working Memory Versus Inhibitory Control in Adolescent ADHD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 12-18 years
- Participant and parent are fluent in English and able to provide informed consent/assent
- Clinical diagnosis of ADHD confirmed by diagnostic interview
- Parent rating on BRIEF-2 showing working memory and inhibition scale T-Scores greater than 60
- IQ greater than 70
You will not qualify if you...
- Intracranial pathology from genetic or acquired neurologic disorders, cerebral palsy, severe head injury, or significant dysmorphology
- History of fainting spells of unknown cause possibly related to seizures
- History of seizures, epilepsy diagnosis, or immediate family history of epilepsy
- Progressive neurological disorders
- Uncontrolled chronic medical conditions that may cause emergencies if seizures occur
- Contraindicated metal implants in head, brain, or spinal cord (excluding dental implants/fillings)
- Non-removable makeup or piercings
- Presence of pacemaker, implanted medication pump, or ventriculo-peritoneal shunt
- Use of vagal nerve stimulator, deep brain stimulator, or transcutaneous electrical nerve stimulation
- Signs of increased intracranial pressure or intracranial lesions
- History of head injury causing prolonged loss of consciousness
- Substance abuse or dependence within past six months
- Chronic use of medications lowering seizure threshold, excluding medically safe psychostimulants
- Active psychosis or mania
- Acute suicidal intent
- Current pregnancy
- Significant visual, hearing, or speech impairments
- Presence of dental braces
- Current wards of the state
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
E. P. Bradley Hospital
East Providence, Rhode Island, United States, 02915
Actively Recruiting
Research Team
B
Brian K Kavanaugh, PsyD; PI, PsyD ABPP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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