Actively Recruiting
Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression
Led by Rotman Research Institute at Baycrest · Updated on 2025-10-28
24
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol can reduce depressive symptoms in older adults (ages 60-85) with Major Depressive Disorder (MDD) who have not tolerated or responded to antidepressant medications. The study will evaluate whether accelerated dTMS administered over 5 consecutive days is safe and well-tolerated in this population, and whether it produces greater reductions in depressive symptoms compared to placebo stimulation.
CONDITIONS
Official Title
Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Are between 60 and 85 years old on the day of randomization
- Diagnosed with DSM5 Major Depressive Disorder with the current episode lasting longer than 4 weeks but less than 5 years
- Have not responded to, not tolerated, or failed to achieve remission with at least one antidepressant trial of 8 weeks or longer
- Willing to provide informed consent
- Able to follow the treatment schedule
- Stable on medications for at least 2 months and not expected to change medication during the study
- Have passed a satisfactory safety screening questionnaire for TMS
You will not qualify if you...
- Have a metal plate or implant in the head such as ear implants, implanted brain stimulators, or aneurysm clips (non-magnetic dental devices are allowed)
- Have known or history of increased brain pressure that may increase seizure risk
- Have a cardiac pacemaker
- Have an implanted medication pump
- Have a central venous line
- Have a history of psychotic disorder, bipolar disorder, eating disorder, obsessive compulsive disorder, post-traumatic stress disorder, or dementia
- Have a history of substance abuse in the last 6 months
- Have a history of stroke or other brain lesions
- Have a personal or family history of epilepsy
- Are pregnant or breastfeeding
- Have a history of abnormal brain MRI
- Have untreated hypo- or hyper-thyroidism
- Have unstable medical conditions
- Have other known contraindications to TMS
- Are on unstable doses of psychotropic medications such as antidepressants, antipsychotics, mood stabilizers, or memory enhancers
- Require daily benzodiazepines or hypnotics within 2 weeks of randomization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rotman Research Institute at Baycrest
Toronto, Ontario, Canada, M6A 2E1
Actively Recruiting
Research Team
A
Amanda Chao, MPH
CONTACT
L
Linda Mah, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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