Study of Accelerated Partial Breast Irradiation Using Stereotactic Body Radiation Therapy in Women With Early Breast Cancer

What this Trial Is About

Researchers are investigating the safety and effectiveness of Accelerated Partial Breast Irradiation APBI using a specialized radiation technique called Stereotactic Body Radiation Therapy SBRT in women with certain types of breast cancer. This observational study focuses on women aged 50 to 100 with low to intermediate grade ductal carcinoma in situ or invasive ductal carcinoma, aiming to assess outcomes over a five-year follow-up period. Participants will receive a targeted radiation dose of 30 Gy divided into five treatments, delivered over alternating days within 5 to 10 days. Before treatment, fiducial markers are placed to guide precise radiation targeting. Imaging techniques such as CT scans, MRI, and PET may be used for motion assessment, and different equipment setups like gantry-based linear accelerators or robotic systems CyberKnife are utilized depending on the case. The radiation targets the tumor cavity with defined margins while protecting surrounding organs and tissues. During the study, participants will undergo regular imaging and assessments to monitor breast appearance, acute toxicities within 6 weeks, and late side effects up to 5 years. Researchers will measure cosmetic outcomes using standardized scales and record any adverse events related to treatment. The study includes detailed dosimetry and safety monitoring to evaluate the treatments impact over time.

Accelerated Partial Breast Irradiation (APBI) Using Stereotactic Body Radiation Therapy (SBRT)