Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06432972

Accelerated Pulmonary Rehabilitation in the Preoperative Period

Led by University of Vermont · Updated on 2026-03-23

20

Participants Needed

1

Research Sites

130 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This proposed project will be a single arm, non-masked study. Participants who are actively smoking with a diagnosis of a new lung nodule, either confirmed or suspicious for lung cancer, with a plan for lung cancer treatment with or without surgical resection will be recruited from the University of Vermont Medical Center (UVMMC)pulmonary, cardiothoracic surgery, and Lung Multidisciplinary Clinic (LMDC). All patients will be enrolled in prehab and offered smoking cessation therapy. The acceptability and feasibility of this intervention will be measured by percent enrollment in study, attendance, barriers to completion, and monitoring of adverse events. The effect of prehab will be measured by traditional metrics, including fitness, respiratory symptoms, and depression scale. Research outcomes will be measured by smoking habits, anxiety, and surgical complications. Investigators estimate that 20 participants over a two-year period will be sufficient to measure the safety and feasibility of this study. Investigators aim to enroll, on average, 2 participants per month in order to complete this study in a timely fashion. Participants will be enrolled in prehab on a rolling basis, as to not delay surgical timeline.

CONDITIONS

Official Title

Accelerated Pulmonary Rehabilitation in the Preoperative Period

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Lung nodule highly suspicious for lung cancer based on imaging and physician assessment
  • Eligible for lung cancer treatment
  • Current smoker of at least 5 cigarettes per day
  • Willing to attempt smoking cessation during the rehab period
  • Willing to use nicotine replacement therapy and varenicline
  • Able to attend 16 pulmonary rehab sessions at UVMMC over 8 days
  • Able and willing to provide informed consent
Not Eligible

You will not qualify if you...

  • Unsafe to participate in pulmonary rehab due to unstable heart or vascular disease, musculoskeletal issues, or significant psychiatric or cognitive conditions
  • Unable to consistently attend pulmonary rehab sessions
  • Pregnant, based on self-report
  • Currently or recently in another clinical trial that could affect this study
  • Any other condition judged by doctors to risk patient safety or research integrity

AI-Screening

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Trial Site Locations

Total: 1 location

1

University of Vermont Medical Center

Burlington, Vermont, United States, 05401

Actively Recruiting

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Research Team

O

Olivia J Garrow, MS, RDN

CONTACT

S

Sophie Macner

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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