Actively Recruiting
Accelerated Pulmonary Rehabilitation in the Preoperative Period
Led by University of Vermont · Updated on 2026-03-23
20
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This proposed project will be a single arm, non-masked study. Participants who are actively smoking with a diagnosis of a new lung nodule, either confirmed or suspicious for lung cancer, with a plan for lung cancer treatment with or without surgical resection will be recruited from the University of Vermont Medical Center (UVMMC)pulmonary, cardiothoracic surgery, and Lung Multidisciplinary Clinic (LMDC). All patients will be enrolled in prehab and offered smoking cessation therapy. The acceptability and feasibility of this intervention will be measured by percent enrollment in study, attendance, barriers to completion, and monitoring of adverse events. The effect of prehab will be measured by traditional metrics, including fitness, respiratory symptoms, and depression scale. Research outcomes will be measured by smoking habits, anxiety, and surgical complications. Investigators estimate that 20 participants over a two-year period will be sufficient to measure the safety and feasibility of this study. Investigators aim to enroll, on average, 2 participants per month in order to complete this study in a timely fashion. Participants will be enrolled in prehab on a rolling basis, as to not delay surgical timeline.
CONDITIONS
Official Title
Accelerated Pulmonary Rehabilitation in the Preoperative Period
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Lung nodule highly suspicious for lung cancer based on imaging and physician assessment
- Eligible for lung cancer treatment
- Current smoker of at least 5 cigarettes per day
- Willing to attempt smoking cessation during the rehab period
- Willing to use nicotine replacement therapy and varenicline
- Able to attend 16 pulmonary rehab sessions at UVMMC over 8 days
- Able and willing to provide informed consent
You will not qualify if you...
- Unsafe to participate in pulmonary rehab due to unstable heart or vascular disease, musculoskeletal issues, or significant psychiatric or cognitive conditions
- Unable to consistently attend pulmonary rehab sessions
- Pregnant, based on self-report
- Currently or recently in another clinical trial that could affect this study
- Any other condition judged by doctors to risk patient safety or research integrity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Vermont Medical Center
Burlington, Vermont, United States, 05401
Actively Recruiting
Research Team
O
Olivia J Garrow, MS, RDN
CONTACT
S
Sophie Macner
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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