Actively Recruiting
Effectiveness of Accelerated Rehabilitation on Knee Joint Function and Quality of Life in Individuals With Total Knee Arthroplasty: A Double Blind Randomized Controlled Trial
Led by Mahidol University · Updated on 2026-01-06
32
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of an accelerated rehabilitation program compared to conventional rehabilitation for individuals aged 50 to 80 years undergoing primary unilateral total knee arthroplasty (TKA) due to knee osteoarthritis. This double-blind randomized controlled trial aims to assess improvements in knee joint function and quality of life following surgery. The study is conducted in Dali, Yunan, China, and seeks to provide important insights into post-operative recovery for TKA patients. Participants will be randomly assigned to one of two groups: an accelerated rehabilitation group using exercise based on optimal and accelerated concepts, or a conventional rehabilitation group following routine exercise programs. Both programs focus on rehabilitation after total knee replacement and will be followed for six months post-surgery to evaluate longer-term outcomes. During the study, participants will have their knee function assessed using the Knee injury and Osteoarthritis Outcome Score (KOOS) from enrollment through the six-month follow-up. Quality of life will also be measured using the SF-36 surveys. The trial will monitor participants' recovery progress, functional outcomes, and overall well-being after surgery under controlled conditions.
CONDITIONS
Brief Title
Accelerated Rehabilitation in Individuals After Total Knee Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with end-stage knee osteoarthritis requiring primary unilateral total knee arthroplasty
- Aged between 50 and 80 years
- Able to follow a structured rehabilitation protocol
- Both genders are eligible
You will not qualify if you...
- History of joint infections, cancer, or inflammatory arthritis
- End-stage osteoarthritis due to rheumatoid or septic arthritis
- Neurological disorders such as Alzheimer's disease, Parkinson's disease, or stroke
- Unable to follow a structured rehabilitation protocol
- Previous knee surgeries other than arthroscopy
- Severe comorbidities hindering participation, such as advanced cardiovascular diseases
- Severe osteoporosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 6 months
Participants undergo accelerated or conventional rehabilitation exercises after total knee arthroplasty.
Regular rehabilitation sessions as per protocol
Duration - 6 months post-treatment
Participants are monitored for knee joint function and quality of life after completing rehabilitation.
Periodic visits during follow-up
Trial Site Locations
Total: 1 location
1
Hospital
Dali, Yunnan, China
Actively Recruiting
Research Team
L
Liying Yang, PT, M.Sc.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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