Study of Accelerated Repetitive Transcranial Magnetic Stimulation with Psychotherapy in Hospitalized Adults With Obsessive-Compulsive Disorder

What this Trial Is About

Researchers are evaluating a new treatment approach for adults with Obsessive-Compulsive Disorder OCD, a condition marked by unwanted repetitive thoughts and behaviors. This study aims to determine whether combining specialized inpatient care with repetitive Transcranial Magnetic Stimulation rTMS is feasible, well-tolerated, and effective. Two types of rTMS will be tested deep TMS dTMS and intermittent theta burst stimulation iTBS, using an accelerated protocol over two weeks. Participants will be randomly assigned to one of three groups one group will receive dTMS plus Exposure and Response Prevention ERP, another will receive iTBS plus ERP, and the third will receive ERP alone without rTMS. Both rTMS treatments involve four sessions per day, four days per week, totaling 32 sessions over two weeks. ERP therapy includes cognitive behavioral techniques, psychoeducation, and exposure exercises, with family involvement. The treatment occurs during a twelve-week hospitalization. During the study, participants complete questionnaires before, immediately after, and four weeks post-treatment. Brain imaging MRI and brain wave recordings EEG are done before and after treatment. Patients keep a daily diary of any side effects during rTMS. Researchers will monitor safety, feasibility, clinical outcomes, and brain changes related to treatment. Total participation lasts about ten weeks, integrated into usual inpatient care including medication and psychotherapy.

Accelerated rTMS in Hospitalized Patients With OCD: a Feasibility and Mechanistic Study