Substance Use Disorder Treatment With Accelerated Repetitive Transcranial Magnetic Stimulation for Depression

What this Trial Is About

Researchers are studying an accelerated form of repetitive transcranial magnetic stimulation (rTMS) for people with depression and stimulant use disorder, including methamphetamine or cocaine use disorder. This is a small, open-label feasibility trial aiming to understand how well this accelerated rTMS treatment can be given and tolerated in this group. The study is sponsored by the University of Texas Southwestern Medical Center and involves participants already enrolled in an ongoing stimulant use disorder study. Participants who qualify will receive up to 50 sessions of rTMS over three weeks, with up to four short sessions each day and up to five days per week. The sessions use intermittent theta burst stimulation targeting the left dorsolateral prefrontal cortex. A follow-up visit is scheduled one week after the final rTMS session to monitor progress. During the study, participants will undergo EEG and ECG tests, urine drug screens, and complete both self-report and clinician-rated assessments related to stimulant use, craving, depression, irritability, and suicidality. Researchers will measure how feasible the accelerated rTMS course is, its effects on stimulant use and craving, and changes in symptoms over the treatment and follow-up periods. Total participation lasts approximately four weeks including treatment and follow-up.

Accelerated rTMS for Substance Use Disorder and Depression