Actively Recruiting
Accelerated rTMS for Substance Use Disorder and Depression
Led by University of Texas Southwestern Medical Center · Updated on 2025-07-31
40
Participants Needed
1
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a small open-label feasibility trial of an accelerated course of repetitive transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant use disorder \[including methamphetamine or cocaine use disorder (MUD/CUD)\].
CONDITIONS
Official Title
Accelerated rTMS for Substance Use Disorder and Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be aged 18-65 years, inclusive.
- Understand, speak, and read English well enough to give informed consent and follow study instructions.
- Self-report stimulant use (cocaine, methamphetamine, or prescription stimulants) at least 10 days in the 30 days before consent.
- Have a diagnosis of moderate or severe Cocaine or Methamphetamine Use Disorder or other Stimulant Use Disorder in the past 12 months.
- Have a PHQ9 score of 5 or higher.
- Be willing to provide urine samples, EEGs, and ECGs.
- If of childbearing potential, be willing to use birth control during the treatment phase.
You will not qualify if you...
- Current use of alcohol, benzodiazepines, or other sedatives that would make participation unsafe.
- History of serious medical disorders that prevent safe participation or data collection.
- History of unprovoked seizures or any seizures in the past 6 months.
- History of brain lesions or tumors.
- Have metal implants or non-removable metal objects above the neck.
- Current pregnancy.
- Current or past manic or hypomanic episodes.
- Current psychotic disorder.
- Being a prisoner or in police custody at screening.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UT Southwestern Medical Center
Dallas, Texas, United States, 75247
Actively Recruiting
Research Team
T
Taylor Helmbrecht, B.S.A.
CONTACT
T
Teresa Slettebo, B.A.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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