Study of Accelerated Transcranial Magnetic Stimulation Targeting the Inferior Frontal Cortex to Treat Obsessive-Compulsive Disorder in Adults

What this Trial Is About

Researchers are evaluating whether individualized accelerated repetitive transcranial magnetic stimulation rTMS targeting the inferior frontal cortex combined with symptom provocation can relieve obsessive-compulsive disorder OCD symptoms in adults. The study also aims to assess the safety of rTMS applied to the right inferior frontal cortex. It focuses on adults with OCD resistant to standard treatments and seeks to answer questions about symptom relief and medical problems during rTMS treatment. Participants will receive rTMS six times daily for five consecutive days, targeting a personalized area of the inferior frontal cortex while provoking symptoms. The study involves a baseline clinic visit, treatment days, and follow-up visits on the day after treatment and four weeks later. The approach uses a non-invasive brain stimulation technique designed to assess its effects on OCD symptoms. During the study, participants will undergo evaluations including symptom severity assessments using the Yale-Brown Obsessive Compulsive Scale Y-BOCS from baseline up to six months after treatment. Additional tests include safety monitoring for adverse events, depression and anxiety scales, clinical efficacy measures, neuroimaging by MRI, cognitive function tasks, and self-rated questionnaires. Participants will be closely monitored through clinic visits and various assessments over the study period.

Accelerated rTMS Therapeutic Approach for Refractory Obsessive-Compulsive Disorder