Actively Recruiting

Phase Not Applicable
Age: 18Years - 60Years
All Genders
NCT07198594

Accelerated rTMS Therapeutic Approach for Refractory Obsessive-Compulsive Disorder

Led by Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University · Updated on 2025-09-30

20

Participants Needed

1

Research Sites

130 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to learn if individualized accelerated repetitive transcranial magnetic stimulation (rTMS) targeting the inferior frontal cortex combined with symptom provocation works to treat obsessive-compulsive disorders (OCD) in adults. It will also learn about the safety of rTMS over right IFC. The main questions it aims to answer are: * Does rTMS using a new individualized IFC target relieve participants' OCD symptoms? * What medical problems do participants have when taking rTMS? Participants will: * Take rTMS six times per day for 5 consecutive days * Visit the clinic once at baseline, the day and four weeks after treatment for checkups and tests

CONDITIONS

Official Title

Accelerated rTMS Therapeutic Approach for Refractory Obsessive-Compulsive Disorder

Who Can Participate

Age: 18Years - 60Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Volunteer subjects with Obsessive Compulsive Disorder (OCD) according to DSM V criteria
  • No associated tics like Gilles de la Tourette Syndrome
  • Age between 18 and 60 years, right-handed
  • Yale-Brown Obsessive Compulsive Scale score of 16 or higher
  • Stable medication for at least 4 weeks
  • Resistant to standard treatments with partial or insufficient response
  • No systematic rTMS therapy in the past six months
  • Signed informed consent form
  • Normal or corrected vision
  • Ability to complete protocol-specified tests
Not Eligible

You will not qualify if you...

  • Abnormal cognitive status with MoCA score below 24
  • Primary diagnosis other than OCD (mild depression allowed)
  • Comorbid schizophrenia, psychotic disorder, bipolar disorder, or substance abuse
  • Significant self-harm intent or severe suicidal tendencies within the past year
  • Irreversible visual or auditory impairment
  • Presence of metallic implants such as pacemakers or stents
  • Medical, psychological, social, or geographical factors compromising safety or participation
  • Poor compliance
  • Claustrophobia
  • History of epilepsy or familial epilepsy
  • Pregnant or lactating women without negative pregnancy test and contraceptive use
  • Deterioration or failure of vital organ function or unstable vital signs
  • Conditions unsuitable for stimulation site like increased intracranial or intraocular pressure
  • History or presence of neurological disorders or significant somatic diseases affecting brain function

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Shanghai Pudong New Area Mental Health Centre

Shanghai, Shanghai Municipality, China, 200124

Actively Recruiting

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Research Team

Y

Yijie Zhao

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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