Actively Recruiting
Accelerated TMS for MDD
Led by Neuronetics · Updated on 2025-11-21
50
Participants Needed
3
Research Sites
123 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
An open-label, multi-center, prospective study to evaluate feasibility and efficacy of accelerated TMS for patients with Major Depressive Disorder (MDD).
CONDITIONS
Official Title
Accelerated TMS for MDD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female
- 15 years and older
- Able to provide informed consent or assent
- Diagnosed with major depressive disorder (MDD) and currently experiencing a major depressive episode (MDE)
- Adults must have failed to respond to at least one prior antidepressant medication; adolescents may use TMS as adjunct treatment without prior failure
- Prescribed TMS therapy for MDD by their physician independent of study participation
- On a stable antidepressant treatment regimen for at least 4 weeks and agree to maintain it during the study
- Willing to comply with all study procedures, assessments, and visits, and available for study duration
You will not qualify if you...
- Contraindications for TMS per current treatment guidelines
- MADRS score below 20 or PHQ score below 10 at screening or baseline
- Current diagnosis of substance use disorder except nicotine dependence
- Symptoms of substance withdrawal
- History of schizophrenia, schizoaffective disorders, or psychotic symptoms in current or previous depressive episodes
- Any disorder clinically predominant over MDD at screening or within 6 months prior
- Clinically significant abnormality at screening affecting safety or study participation
- Participation in any clinical trial with investigational drug or device within past month or concurrent
- History of non-response to TMS or electroconvulsive therapy (ECT)
- History of implanted device or psychosurgery for depression
- Considered at significant risk for suicide by investigator
- Any medical or psychological condition that would prevent study completion or affect data integrity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Brighter Neurotherapeutics
New York, New York, United States, 10010
Actively Recruiting
2
TMS of the Carolinas
Charlotte, North Carolina, United States, 28210
Actively Recruiting
3
New chapter TMS
Spokane, Washington, United States, 99202
Actively Recruiting
Research Team
N
Neha Goyal
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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