Actively Recruiting
Accelerating Delivery of Rheumatic Heart Disease Preventive Interventions in Northern Uganda
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2026-05-15
221
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital Medical Center, Cincinnati
Lead Sponsor
U
Uganda Heart Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to evaluate the feasibility, sustainability, and public health impact of a district-based program for secondary prevention of Rheumatic Heart Disease (RHD) in Uganda. It is a non-randomized study testing the implementation of decentralized RHD preventive services, overseen by the Uganda Ministry of Health and District Health Offices in partnership with a technical quality assurance team. The study uses the RE-AIM framework to measure program reach, effectiveness, adoption, implementation, and maintenance while also estimating cost-effectiveness and budget impact. The study involves the ADUNU program, which integrates echocardiographic screening for RHD in children and young adults through community and facility-based testing. The program also includes registry-based secondary prophylaxis injections of Benzathine penicillin G (BPG) administered at local health centers (HCIII and HCIV) in the participating districts. This approach is designed to improve access to care and maintain patients linked to treatment. Participants and healthcare providers residing or working in the involved districts will engage with the program over several years. Researchers will assess the proportion of persons reached, enrolled, retained, and adherent to treatment at multiple time points up to five years. They will also evaluate program adoption and implementation at organizational, provider, and patient levels through surveys and interviews, alongside a cost analysis of the program at three years. The study ensures ongoing monitoring of adherence and outcomes to understand the program's public health impact.
CONDITIONS
Brief Title
Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Residing in one of two involved districts in Uganda
- Healthcare providers working at HCIII and HCIV health centers in one of the two involved districts
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants who undergo routine care are observed as part of the ADUNU program that integrates echocardiographic screening and registry-based care for rheumatic heart disease.
Periodic visits depending on care schedule at local health centers
Trial Site Locations
Total: 1 location
1
Uganda Heart Institute
Kampala, Uganda, Uganda
Actively Recruiting
Research Team
N
Ndate Fall
M
Mary Banks
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
1
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