Effect of Short-term Homebased Pre- and Postoperative Exercise on Recovery After Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial.
Aron Onerup, John Andersson, Eva Angenete...
https://pubmed.ncbi.nlm.nih.gov/33843798Actively Recruiting
Led by NICHD Pelvic Floor Disorders Network · Updated on 2026-04-27
288
Participants Needed
7
Research Sites
39 weeks
Total Duration
N
NICHD Pelvic Floor Disorders Network
Lead Sponsor
R
RTI International
Collaborating Sponsor
Researchers are evaluating the physical recovery of women undergoing minimally invasive surgery for Pelvic Organ Prolapse (POP). This study compares recovery times between women who receive routine postoperative instructions and those who follow a prescribed exercise program. The goal is to see if early exercise after surgery leads to faster recovery without negatively affecting pelvic floor health or surgical outcomes. Participants will be randomly assigned to either a control group receiving standard postoperative advice or an intervention group instructed to perform 30 minutes of medium-intensity exercise starting on postoperative day 3, at least five times weekly for six weeks. All participants will wear an accelerometer on their non-dominant wrist to objectively measure physical activity before and after surgery. Recovery progress will be tracked daily through a mobile app until participants report feeling mostly recovered. During the study, participants will complete physical tests and questionnaires at baseline, 2, 6, and 12 weeks post-surgery, with a final assessment one year after surgery. Researchers will monitor recovery status, pelvic floor symptoms, activity adherence, and anatomical outcomes. Data collection includes self-reported recovery, accelerometer readings, physical performance tests, and clinical evaluations, with safety and adverse events recorded throughout the study period.
CONDITIONS
Accelerometer Measured Early Recovery After Prolapse Surgery
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 1 day
Participants undergo minimally invasive surgery for pelvic organ prolapse followed by initial postoperative recovery.
1 hospital stay (in-person)
Duration - 6 weeks
Participants follow either a prescribed early exercise regimen starting on postoperative day 3 or receive standard postoperative care with gradual resumption of activity.
Continuous accelerometer wear during waking hours, daily mobile app queries, and 2 in-person visits at 2 and 6 weeks for data collection
Duration - Up to 1 year after surgery
Participants are monitored remotely via a mobile app until 12 weeks post surgery and attend in-office evaluations at 12 weeks and 1 year to assess recovery and outcomes.
In-person visits at 12 weeks and 1 year
Total: 7 locations
1
Kaiser Permanente -- San Diego
San Diego, California, United States, 92110
Actively Recruiting
2
University of California - San Diego
San Diego, California, United States, 92121
Actively Recruiting
3
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
4
Duke University, Duke Division of Urogynecology and Reconstructive Pelvic Surgery
Durham, North Carolina, United States, 27707
Actively Recruiting
5
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
6
Brown/ Women and Infants Hospital of Rhode Island, Division of Urogynecology and Reconstructive Pelvic Surgery
Providence, Rhode Island, United States, 02903
Actively Recruiting
7
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Not Yet Recruiting
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Have more questions? Get in touch with our team for quick support
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Aron Onerup, John Andersson, Eva Angenete...
https://pubmed.ncbi.nlm.nih.gov/33843798R C Bump, A Mattiasson, K Bø...
https://pubmed.ncbi.nlm.nih.gov/8694033Vivian W Sung, Nicole Kauffman, Christina A Raker...
https://pubmed.ncbi.nlm.nih.gov/18313632C J Jones, R E Rikli, W C Beam
https://pubmed.ncbi.nlm.nih.gov/10380242Karon F Cook, Winnie Dunn, James W Griffith...
https://pubmed.ncbi.nlm.nih.gov/23479545Matthew D Barber, Kim Kenton, Nancy K Janz...
https://pubmed.ncbi.nlm.nih.gov/22777368Ilker Yalcin, Richard C Bump
https://pubmed.ncbi.nlm.nih.gov/12861145M D Barber, M D Walters, R C Bump
https://pubmed.ncbi.nlm.nih.gov/16021067Ingrid E Nygaard, Erin Clark, Lauren Clark...
https://pubmed.ncbi.nlm.nih.gov/28073797Maike Liebermann, Michael Awad, Megan Dejong...
https://pubmed.ncbi.nlm.nih.gov/23635615