Actively Recruiting
Acceptability and Adherence to Different Dosing Regimens of the Multistrain Probiotic Vivomixx® 460 Neo 9 in Adults Receiving Antibiotic Therapy.
Led by University of Thessaly · Updated on 2026-02-02
40
Participants Needed
1
Research Sites
24 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This open-label interventional study aims to evaluate the acceptability and adherence of adult participants to the multistrain probiotic Vivomixx® 460 Neo 9 when administered concurrently with antibiotic therapy. Participants are randomized to receive one of two dosing regimens: a low daily dose or a high daily dose. The study will assess the effects of these regimens on the prevention of antibiotic-associated diarrhea (AAD), gastrointestinal symptoms, and patient adherence and acceptability. The results are intended to provide evidence to optimize the clinical use of probiotics alongside antibiotics.
CONDITIONS
Official Title
Acceptability and Adherence to Different Dosing Regimens of the Multistrain Probiotic Vivomixx® 460 Neo 9 in Adults Receiving Antibiotic Therapy.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged over 18 years
- Starting oral antibiotic therapy lasting more than 3 days
- History of diarrhea during previous antibiotic treatment
- Eligible antibiotics include amoxicillin with clavulanic acid, clindamycin, or second- or third-generation cephalosporins
- Willingness to provide informed consent to participate in the study
You will not qualify if you...
- Pregnancy or breastfeeding
- Age under 18 years
- Diagnosis of a chronic autoimmune disease (e.g., Crohn's disease, ulcerative colitis, rheumatoid arthritis, psoriasis)
- Diagnosis of type I or type II diabetes
- Renal or hepatic disease
- Current use of immunosuppressive medications
- Current use of other supplements, probiotics, prebiotics, or synbiotics
- Use of antibiotics within the past month
- Use of laxatives or antidiarrheal medications within the past 2 weeks
- Pre-existing diarrhea within the past 2 weeks
- Self-reported allergy to any component of the probiotic
- Psychological conditions affecting the ability to provide informed consent (e.g., dementia, psychosis, substance use)
- Gastrointestinal surgery within the past 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
School of Physical Education, Sport Science and Dietetics
Trikala, Greece, 42132
Actively Recruiting
Research Team
V
VAIOS SVOLOS, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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