Global timing of hepatitis C virus elimination in high-income countries.
Homie Razavi, Yuri Sanchez Gonzalez, Cammy Yuen...
https://pubmed.ncbi.nlm.nih.gov/31815353/Actively Recruiting
Led by University Hospital, Limoges · Updated on 2022-05-04
1500
Participants Needed
1
Research Sites
374 weeks
Total Duration
This research aims to evaluate the acceptability of simultaneous screening for viral Hepatitis B, Hepatitis C, and HIV among drug users in non-conventional care settings. The study involves coordinated monthly screening days where health professionals including hepatologists, addictologists, nurses, and social workers work together to assess and provide appropriate management for each participant. This approach is designed to offer comprehensive screening and care in a supportive environment outside traditional healthcare facilities. The screening process includes several steps patients visiting on screening days receive individualized attention and data collection by the care team. They are offered rapid diagnostic tests TRODs for Hepatitis B, C, and HIV, and a FibroScan to assess liver health. Positive results lead to additional tests like delocalized PCR for Hepatitis C RNA or blood tests for HIV and Hepatitis B serologies. Immediate consultation with a hepatologist follows, with confidential result delivery and discussion of further care options. Prevention advice and vaccination for Hepatitis B may also be provided. Participants engage in routine care procedures, including diagnostic tests and consultations during the screening days. Researchers monitor the number of tests performed, patient attendance, acceptance of consultations, vaccination rates, treatment initiations, and treatment adherence over a period of up to 10 years. This long-term follow-up helps assess the programs impact on managing viral infections among drug users, with ongoing support provided by the healthcare team throughout the study duration.
CONDITIONS
Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Structures
M
Marilyne DEBETTE-GRATIEN, MD
V
Véronique LOUSTAUD-RATTI, Prof
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University Hospital, Limoges
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Same day
Participants undergo simultaneous rapid diagnostic tests for viral Hepatitis B, C, and HIV along with a FibroScan to assess liver condition. Positive tests may lead to immediate additional blood tests or PCR testing and consultation with a hepatologist.
1 visit (in-person)
Duration - Up to 10 years
Participants who test positive may start treatment immediately and have follow-up appointments, including a control test approximately 3 months after treatment to confirm cure. Prevention and vaccination may also be offered during this period.
Follow-up visits as scheduled, including a control visit at 3 months post-treatment
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Lead Sponsor