Acellular Collagen Matrix as a Tool to Obtain Wound Closure Following Guided Bone Regeneration Procedures

What this Trial Is About

Researchers are evaluating the use of an acellular collagen matrix to improve wound healing after guided bone regeneration (GBR) procedures in patients who need increased bone volume in the jaw before dental implant placement. This study compares healing outcomes between patients whose wound is closed with the acellular matrix versus those who receive traditional surgical closure without it. The study focuses on early wound healing and aims to assess whether the acellular matrix helps prevent shallow vestibulum formation and reduces the need for additional surgeries. During the GBR procedure, bone grafting material is placed in the jawbone defect and covered with a barrier membrane. When the membrane is exposed due to limited tissue coverage, the acellular matrix may be placed over it to aid healing. Patients receive either the acellular matrix covering or standard surgical closure without the matrix, based on their dental surgeon's judgment. Standard postoperative care including antibiotics, pain control, and antiseptic mouthwash is provided. The study collects additional clinical and radiographic measurements before and after surgery, along with patient-reported experience data. Participants will have follow-up visits at 8-10 days, 6-8 weeks, and 4-6 months after surgery, during which wound healing will be assessed through clinical exams, CBCT scans, and implant stability checks. The study will measure healing scores and ridge dimension changes over time. Each visit may last about 40 minutes longer than routine appointments due to research-related assessments. The total observation period lasts up to 4-6 months, ending around the time of implant placement surgery.

Acellular Collagen Matrix as a Tool to Obtain Wound Closure Following a Guided Bone Regeneration Procedure