Actively Recruiting
Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial
Led by University of California, San Diego · Updated on 2025-06-17
25
Participants Needed
1
Research Sites
145 weeks
Total Duration
On this page
Sponsors
U
University of California, San Diego
Lead Sponsor
B
Breakthrough T1D
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to learn about the effect of the study drug acetazolamide in individuals with Type 1 Diabetes. Specifically, whether acetazolamide provides benefits to the kidneys while minimizing any side effects of the drug. These changes will be measured by laboratory tests that tell us how well the kidneys are functioning.
CONDITIONS
Official Title
Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females 18 years or older at the time of consent
- Individuals able to become pregnant must be at least 1 year post-menopausal or surgically sterile, or agree to use two contraception methods during the study
- Individuals able to cause pregnancy must agree to use clinically acceptable contraception during the study
- Clinical diagnosis of Type 1 Diabetes with stable medication regimen for at least 3 months
- Estimated glomerular filtration rate (eGFR) of 45 ml/min/1.73m2 or higher
- Serum bicarbonate level of 24 meq/L or higher
- Negative urine toxicology screen
- Able to provide written informed consent approved by an Institutional Review Board (IRB)
You will not qualify if you...
- History of allergic reaction to acetazolamide, other carbonic anhydrase inhibitors, or inactive ingredients in the tablets
- Liver disease including cirrhosis or high liver enzyme levels
- Hemoglobin A1c greater than 10.0%
- Hemoglobin concentration less than 8 g/dL
- Use of more than 4 anti-hypertensive medications or systolic blood pressure above 160 mm Hg at screening
- Use of loop, thiazide, or potassium-sparing diuretics
- Medical conditions requiring urgent surgical or medical intervention such as active cardiac or pulmonary issues, ongoing ischemia, uncorrected coronary artery disease, or heart failure
- Institutionalized individuals like prisoners, those with significant mental illness, or nursing home residents
- Active pregnancy, breastfeeding, or planning pregnancy during the study
- Current participation in another clinical trial (observational studies excluded)
- Inability to adhere to study regimen or comply with recommendations
- Inability or unwillingness to travel to study visits
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UC San Diego Altman Clinical & Translational Research Institute
La Jolla, California, United States, 92037
Actively Recruiting
Research Team
T
Todd May, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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