Studying Heart Function Changes Using MRI and Echocardiography in Adults with Alcohol-Related Liver Cirrhosis Undergoing Transjugular Intrahepatic Portosystemic Shunt TIPSS Placement

What this Trial Is About

Researchers are investigating how often symptoms of heart failure develop after a procedure called transjugular intrahepatic portosystemic shunt TIPSS implantation in patients with alcohol-related liver cirrhosis. The study aims to identify laboratory, clinical, and imaging changes linked to this heart condition over a one-year period. This research focuses on improving future treatment approaches and determining exclusion criteria for TIPSS implantation. Participants will undergo three advanced cardiac MRI scans that measure heart function and blood flow in the aorta and pulmonary artery before and after TIPSS implantation. They will also have detailed echocardiography exams to assess heart muscle function and specific blood tests analyzing markers related to inflammation, liver fibrosis, metabolism, and heart remodeling at several time points from before the procedure up to 12 months afterward. Throughout the study, participants will be closely monitored with imaging and laboratory tests before, shortly after, and up to a year following TIPSS implantation. Researchers will evaluate heart function changes and the occurrence of cardiac decompensation. The study includes detailed clinical assessments and blood tests done at multiple visits, allowing comprehensive tracking of participants heart and liver health during this period.

Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients With Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement