Actively Recruiting
Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients with Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement
Led by Stephanie Gräger · Updated on 2025-02-13
80
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
S
Stephanie Gräger
Lead Sponsor
J
Jena University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this clinical trial is to investigate the development of cardiac decompensation following transjugular intrahepatic portosystemic shunt (TIPSS) implantation in order to draw conclusions for future treatment methods or exclusion criteria prior to TIPS implantation. The main questions to be answered are: How often do symptoms of cardiac decompensation develop over a one year period? What laboratory, clinical or imaging morphological changes are associated with this? In addition to the standardised clinical procedure for TIPSS implantation, participants will undergo 3 cardiac magnetic resonance imaging (MRI), extended echocardiographic examinations (both just before, 3 days after and 3 months after implantation) and laboratory chemistry tests for specific endothelial and inflammatory markers (just before, on the day of implantation, 1 day after, 1, 3, 6 and 12 months after implantation).
CONDITIONS
Official Title
Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients with Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 99 years
- Written informed consent of the patient
- Decompensated liver cirrhosis, defined by clinical, imaging or laboratory criteria
- Patient receives an elective TIPSS in the appropriate clinical context at the JUH
You will not qualify if you...
- Pregnancy
- Implants not suitable for magnetic resonance imaging
- Medical or personal reasons against magnetic resonance imaging such as claustrophobia, inability to lie flat, or inability to follow breathing commands
- Patient in critical condition or incompliant
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Jena University Hospital
Jena, Thuringia, Germany, 07747
Actively Recruiting
Research Team
S
Stephanie Gräger
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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