Actively Recruiting
ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma
Led by Nationwide Children's Hospital · Updated on 2026-04-23
30
Participants Needed
14
Research Sites
363 weeks
Total Duration
On this page
Sponsors
N
Nationwide Children's Hospital
Lead Sponsor
C
Children's Hospital Colorado
Collaborating Sponsor
AI-Summary
What this Trial Is About
ACTEMRA (tocilizumab) is an IL-6 receptor antagonist used for the treatment of adult Rheumatoid Arthritis as well as Polyarticular (PJIA) and Systemic (SJIA) Juvenile Idiopathic Arthritis. In this Phase II, the drug will be used to treat pediatric patients diagnosed with recurrent Adamantinomatous Craniopharyngioma including patients who have undergone surgery and/or radiation therapy.
CONDITIONS
Official Title
ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 12 months and 39 years at enrollment
- Histologically confirmed adamantinomatous craniopharyngioma diagnosis
- Measurable disease present
- Stratum 1: Progressive or recurrent ACP at least 6 months after radiation therapy
- Karnofsky score 250% for patients older than 16 years; Lansky score 250 for patients 16 years or younger
- Stable neurological deficits for at least 7 days before enrollment
- Recovery or stabilization from prior acute treatment toxic effects
- Adequate bone marrow, kidney, liver, and neurological function
- Signed informed consent by patient or legal representative
You will not qualify if you...
- Pregnancy or breastfeeding
- Lack of effective contraception for patients of reproductive potential
- History of serious gastrointestinal disease, including inflammatory bowel disease or perforation
- Unstable corticosteroid use or currently receiving other investigational or anti-cancer drugs
- Uncontrolled infections or recent live/attenuated vaccinations within 3 months
- Significant concurrent medical or surgical conditions jeopardizing safety
- History of HIV, Hepatitis B or C, Tuberculosis, or prior solid organ transplant
- Inability to comply with safety monitoring
- History of alcohol, drug, or chemical abuse within 6 months
- Major or intermediate surgery within last 6 weeks or poor wound healing concerns
- Allergic reactions to tocilizumab or similar compounds
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
2
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
3
Nicklaus Children's Hospital
Miami, Florida, United States, 33155
Active, Not Recruiting
4
Duke Children's Hospital
Durham, North Carolina, United States, 27710
Actively Recruiting
5
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
6
Nationwide Children's Hospital
Columbus, Ohio, United States, 43235
Actively Recruiting
7
Texas Children's Hospital
Houston, Texas, United States, 77030
Actively Recruiting
8
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
9
Sydney Children's Hospital
Randwick, New South Wales, Australia, 2031
Actively Recruiting
10
Queensland Children's Hospital
South Brisbane, Queensland, Australia, 4101
Actively Recruiting
11
Perth Children's Hospital
Perth, Western Australia, Australia, 6000
Actively Recruiting
12
Stollery Children's Hospital
Edmonton, Alberta, Canada, T6G2B7
Actively Recruiting
13
The Hospital for Sick Children (SickKids)
Toronto, Ontario, Canada, M5G1X8
Actively Recruiting
14
McGill University Health Center
Montreal, Quebec, Canada
Actively Recruiting
Research Team
K
Kelsey H Troyer, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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