Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
Healthy Volunteers
NCT06489483

Action Regulation Behavioral

Led by University of Texas Southwestern Medical Center · Updated on 2025-12-12

50

Participants Needed

1

Research Sites

183 weeks

Total Duration

On this page

Sponsors

U

University of Texas Southwestern Medical Center

Lead Sponsor

U

University of California, Riverside

Collaborating Sponsor

AI-Summary

What this Trial Is About

Parkinson's disease (PD) is a neurodegenerative disorder involving a part of the brain that is responsible for motor control, which not only results in changes or disruptions in movement, but also cognitive dysfunctions. Given that the decline of muscle control such as tremors, with difficulty walking or the ability to switch tasks once in movement, greatly affects the quality of daily life. Action regulation is a critical executive function (cognitive control over behavior), which includes actions such as suppressing activity when selecting between options, making decisions about stopping unwanted or inappropriate actions, and switching to new actions in response to environmental changes. Parkinson's disease (PD) has been shown to disrupt action inhibition which can be considered a measure to the progression of PD. The purpose of this research study is to better understand the mechanism of action regulations in PD patients and how action regulations in PD can be improved using dopaminergic treatment, which is a drug that either releases or involves dopamine, which is a neurotransmitter involved in sending signals to nerve cells. You are asked to participate in this research study because you are receiving a dopaminergic medication for treatment of your Parkinson's disease. There is currently no theory that integrates the mechanisms of action regulation into a unified framework, which this study aims to address. The researchers hope to learn more about the mechanisms of action regulation in PD patients and to help decrease action regulation disruptions in PD patients. This study will help characterize the motor behavior of PD patients.

CONDITIONS

Official Title

Action Regulation Behavioral

Who Can Participate

Age: 18Years - 80Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of Parkinson's Disease by a movement disorder neurologist
  • Responsive to levodopa with at least 30% improvement in motor scores during "on" periods
  • Willingness and ability to complete behavioral tasks for up to 3.5 hours
  • No vision or hearing problems that impair participation in tasks as assessed by study investigators
  • For healthy subjects: no history of neurological diseases or movement disorders
  • For healthy subjects: no vision or hearing problems that impair task participation
Not Eligible

You will not qualify if you...

  • History of secondary Parkinsonism, stroke, or other progressive central nervous system diseases besides Parkinson's Disease
  • Conditions preventing understanding or communication of consent and study demands, including cognitive decline, diagnosed dementia, significant memory impairment (MoCA<23), or hearing loss preventing communication
  • For healthy subjects: history of neurological diseases or cognitive decline

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Texas Southwestern Medical Center

Dallas, Texas, United States, 75390

Actively Recruiting

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Research Team

N

Nader Pouratian, MD, Phd

CONTACT

S

Sahil Chilukuri, BS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

SINGLE_GROUP

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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Action Regulation Behavioral | DecenTrialz