Actively Recruiting
Action Regulation Behavioral
Led by University of Texas Southwestern Medical Center · Updated on 2025-12-12
50
Participants Needed
1
Research Sites
183 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
U
University of California, Riverside
Collaborating Sponsor
AI-Summary
What this Trial Is About
Parkinson's disease (PD) is a neurodegenerative disorder involving a part of the brain that is responsible for motor control, which not only results in changes or disruptions in movement, but also cognitive dysfunctions. Given that the decline of muscle control such as tremors, with difficulty walking or the ability to switch tasks once in movement, greatly affects the quality of daily life. Action regulation is a critical executive function (cognitive control over behavior), which includes actions such as suppressing activity when selecting between options, making decisions about stopping unwanted or inappropriate actions, and switching to new actions in response to environmental changes. Parkinson's disease (PD) has been shown to disrupt action inhibition which can be considered a measure to the progression of PD. The purpose of this research study is to better understand the mechanism of action regulations in PD patients and how action regulations in PD can be improved using dopaminergic treatment, which is a drug that either releases or involves dopamine, which is a neurotransmitter involved in sending signals to nerve cells. You are asked to participate in this research study because you are receiving a dopaminergic medication for treatment of your Parkinson's disease. There is currently no theory that integrates the mechanisms of action regulation into a unified framework, which this study aims to address. The researchers hope to learn more about the mechanisms of action regulation in PD patients and to help decrease action regulation disruptions in PD patients. This study will help characterize the motor behavior of PD patients.
CONDITIONS
Official Title
Action Regulation Behavioral
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Parkinson's Disease by a movement disorder neurologist
- Responsive to levodopa with at least 30% improvement in motor scores during "on" periods
- Willingness and ability to complete behavioral tasks for up to 3.5 hours
- No vision or hearing problems that impair participation in tasks as assessed by study investigators
- For healthy subjects: no history of neurological diseases or movement disorders
- For healthy subjects: no vision or hearing problems that impair task participation
You will not qualify if you...
- History of secondary Parkinsonism, stroke, or other progressive central nervous system diseases besides Parkinson's Disease
- Conditions preventing understanding or communication of consent and study demands, including cognitive decline, diagnosed dementia, significant memory impairment (MoCA<23), or hearing loss preventing communication
- For healthy subjects: history of neurological diseases or cognitive decline
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
N
Nader Pouratian, MD, Phd
CONTACT
S
Sahil Chilukuri, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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