Actively Recruiting
Activated CHARcoal in Poisoned Patient - Pilot Trial
Led by Laval University · Updated on 2026-01-29
100
Participants Needed
1
Research Sites
80 weeks
Total Duration
On this page
Sponsors
L
Laval University
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical pilot trial is to determine the feasibility of the clinical trial. Then the large-scale CHARPP will be conducted in order to determine the efficacity of activated charcoal as a treatment for acute poisoning in a diverse population of both adults and children suspected of ingesting toxic substances that activated charcoal can adsorb. The main questions it aims to answer are: * Can activated charcoal administered within a specific time frame prevent the progression of toxicity? * How does activated charcoal affect the length of stay in the hospital and the intensive care unit? Researchers will compare the intervention arm (receiving activated charcoal) to the control arm (receiving standard supportive care) to see if activated charcoal reduces hospital stay duration, ICU stay and improves overall patient outcomes. Participants will: * Be randomly assigned to either receive activated charcoal or standard supportive care. * Undergo assessments using standardized clinical scales such as the Poison Severity Score and, for children, the PELODS score. * Have their functional outcomes evaluated, such as the ability to return to their original residence without help and manage personal hygiene tasks independently. This structured approach will help clarify the role of activated charcoal in clinical toxicology and inform future treatment protocols.
CONDITIONS
Official Title
Activated CHARcoal in Poisoned Patient - Pilot Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult and pediatric patients presenting to the hospital less than 6 hours after ingesting a potentially toxic dose of a substance adsorbed by activated charcoal
- Patients able to receive the intervention within 6 hours of confirmed or suspected poisoning
You will not qualify if you...
- Patients requiring or likely to require another gastrointestinal decontamination method
- Patients with contraindications to activated charcoal
- Patients who ingested substances needing multi-dose activated charcoal due to entero-hepatic circulation
- Patients without clinical equipoise for activated charcoal use according to the attending physician
AI-Screening
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Trial Site Locations
Total: 1 location
1
CHU de Québec - Université Laval
Québec, Quebec, Canada, G1J1Z4
Actively Recruiting
Research Team
M
Maude St-Onge, MD PhD FRCPC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
2
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