Actively Recruiting

Phase 4
All Genders
NCT05471479

Activated CHARcoal in Poisoned Patient - Pilot Trial

Led by Laval University · Updated on 2026-01-29

100

Participants Needed

1

Research Sites

80 weeks

Total Duration

On this page

Sponsors

L

Laval University

Lead Sponsor

C

Canadian Institutes of Health Research (CIHR)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this clinical pilot trial is to determine the feasibility of the clinical trial. Then the large-scale CHARPP will be conducted in order to determine the efficacity of activated charcoal as a treatment for acute poisoning in a diverse population of both adults and children suspected of ingesting toxic substances that activated charcoal can adsorb. The main questions it aims to answer are: * Can activated charcoal administered within a specific time frame prevent the progression of toxicity? * How does activated charcoal affect the length of stay in the hospital and the intensive care unit? Researchers will compare the intervention arm (receiving activated charcoal) to the control arm (receiving standard supportive care) to see if activated charcoal reduces hospital stay duration, ICU stay and improves overall patient outcomes. Participants will: * Be randomly assigned to either receive activated charcoal or standard supportive care. * Undergo assessments using standardized clinical scales such as the Poison Severity Score and, for children, the PELODS score. * Have their functional outcomes evaluated, such as the ability to return to their original residence without help and manage personal hygiene tasks independently. This structured approach will help clarify the role of activated charcoal in clinical toxicology and inform future treatment protocols.

CONDITIONS

Official Title

Activated CHARcoal in Poisoned Patient - Pilot Trial

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult and pediatric patients presenting to the hospital less than 6 hours after ingesting a potentially toxic dose of a substance adsorbed by activated charcoal
  • Patients able to receive the intervention within 6 hours of confirmed or suspected poisoning
Not Eligible

You will not qualify if you...

  • Patients requiring or likely to require another gastrointestinal decontamination method
  • Patients with contraindications to activated charcoal
  • Patients who ingested substances needing multi-dose activated charcoal due to entero-hepatic circulation
  • Patients without clinical equipoise for activated charcoal use according to the attending physician

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

CHU de Québec - Université Laval

Québec, Quebec, Canada, G1J1Z4

Actively Recruiting

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Research Team

M

Maude St-Onge, MD PhD FRCPC

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

2

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