The ACTIVE MIND Study Adaptive Cognitive Training to Improve Daily Function and Delay Dementia in Older Adults with Mild Cognitive Impairment

What this Trial Is About

Researchers are investigating the best combination of cognitive training CT exercises to improve daily functioning and delay dementia in older adults with mild cognitive impairment MCI. This adaptive, randomized clinical trial aims to compare different CT combinations against an active control of cognitive stimulation, focusing on reducing the occurrence of dementia. The study also explores related brain imaging and blood-based biomarkers to understand the effects better. Participants will be assigned to one of five groups four groups will complete different combinations of computerized cognitive training exercises, and one group will engage in computerized cognitive stimulation activities. Each participant will complete 40 sessions lasting 60 minutes each, scheduled two to three times per week over 16 weeks. All groups will have equivalent session frequency and duration. Throughout the study, participants will undergo assessments including tests of everyday function such as Timed Instrumental Activities of Daily Living and the iFunction performance efficiency index. Dementia incidence will be monitored during follow-up visits up to two years after the intervention. Cognitive performance, executive function, and attention will also be evaluated immediately after the intervention. The study includes safety monitoring and will last several years to observe long-term outcomes.

The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia