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Study of Active Oxygen-Releasing Gel and Photodynamic Therapy to Improve Treatment of Stage III Periodontitis
Led by Alexandria University · Updated on 2026-04-28
42
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating treatments for stage III periodontitis, a serious gum disease that harms the tissues supporting teeth. The study aims to see if adding an active oxygen-releasing gel, with or without photodynamic therapy, improves outcomes beyond the standard scaling and root planing treatment. Photodynamic therapy uses light and a special dye to target harmful bacteria that cause gum inflammation. The trial randomly assigns 42 patients into three groups. One group receives scaling and root planing plus the oxygen-releasing gel applied to the gums for 3 minutes. The second group receives the same treatment plus photodynamic therapy using a diode laser and a photosensitizer dye. The third group receives only scaling and root planing using ultrasonic tools and curettes. These treatments are given in single sessions. Participants will have their gum health checked at the start, and then one and three months after treatment. Measurements include gingival index, bleeding on probing, pocket depth, and attachment level using periodontal probes. Researchers will also collect bacteria samples from gum pockets to measure specific harmful bacteria levels using quantitative PCR. The study runs until May 2026 and monitors changes over time to evaluate treatment effects.
CONDITIONS
Brief Title
Active Oxygen Releasing Gel With Photodynamic Therapy in Treating Stage III Periodontitis
Research Team
A
Aya Abdelmawla, BDS
A
Aliaa Gamaleldin Aboulela, PhD
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