ACTIVATE A Pilot Randomized Activity Coaching Trial to Increase Energy During Post-operative Pelvic Radiation Therapy for Endometrial Cancer

What this Trial Is About

Fatigue is a common side effect for women undergoing pelvic radiation therapy for endometrial cancer, often making daily activities more difficult. While exercise has been recommended to help with fatigue in cancer patients, there is limited research on its role during pelvic radiation therapy. This trial aims to evaluate whether an activity coaching program can improve treatment-related fatigue in women receiving this therapy. Participants will take part in an exercise coaching program involving ten weekly check-ins with a certified exercise coach. They will set weekly activity goals based on what is easy and enjoyable for them, with check-ins available in person or virtually. Participants will be randomly assigned to start the program either immediately during radiation therapy or after radiation therapy has ended, with the study lasting about six months. All participants will receive a Fitbit to monitor activity, heart rate, and steps. Throughout the study, participants will complete four surveys and perform a 6-minute walk test four times to assess heart and lung response to exercise. At the end of the trial, an interview will be conducted to gather feedback on the program. Researchers will monitor adherence to coaching sessions as the primary outcome, along with changes in fatigue, bowel and urinary symptoms, quality of life, cognitive function, sexual function, self-efficacy, and walking distance. The study aims to follow participants for up to 24 months.

Activity Coaching During Pelvic Radiation Therapy