Actively Recruiting
ACU_Knee: Role of Acupuncture in Knee Prosthetic Surgery
Led by Fondazione IRCCS Policlinico San Matteo di Pavia · Updated on 2025-08-14
80
Participants Needed
1
Research Sites
142 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Post-operative analgesia after total knee arthroplasty (TKA) has always been a challenge in the anesthesiological setting, having to combine good pain control and the need for early mobilization, both factors that can affect the quality of rehabilitation treatment, prosthetic functional outcome, the onset of chronic pain, joint stiffness and the consequent quality of life of the patient. Recent loco-regional anesthesia (LRA) techniques have made an essential contribution to peri-operative management in the fast-track perspective of surgery, in terms of optimization of analgesia and rapid functional recovery. Inadequate post-operative analgesia, by affecting the normal rehabilitation pathway, is associated with medium-long term complications, such as chronic pain, joint stiffness and patient dissatisfaction, which often compromise functional autonomy and quality of life of the patient and may require invasive treatments (surgical revision, unlocking under general anesthesia). The local and systemic inflammatory state, evidenced by peri-operative dosage of specific biomarkers, appears to be related to prosthetic outcome.
CONDITIONS
Official Title
ACU_Knee: Role of Acupuncture in Knee Prosthetic Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged > 18 years
- Patients capable of providing informed consent
- Undergoing unilateral total knee replacement surgery
- Surgery indicated for primary osteoarthritis degeneration
- Surgery performed electively
You will not qualify if you...
- Patients aged < 18 years
- Patients incapable of providing informed consent
- Patients with ASA class > 3
- Pregnant women
- Patients with rheumatoid arthritis or other autoimmune disorders
- Patients with active infection under antibiotic treatment
- Patients on chronic opioid therapy
- Patients on chronic biological drug therapy
- History of corticosteroid use in the six months prior to surgery
- History of periarticular infiltration in the three months prior to surgery
- Contraindications to loco-regional anesthesia
- Contraindications to NSAID, cortisone, and paracetamol therapy
- Bilateral total knee replacement surgery or prosthetic revision surgeries
- Surgery indicated for causes other than primary osteoarthritis degeneration
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Fondazione IRCCS Policlinico San Matteo - SC AR3 - Anestesia e Terapia Intensiva Postchirurgica
Pavia, Pavia, Italy, 27100
Actively Recruiting
Research Team
D
Debora Passador, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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