Actively Recruiting
Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants
Led by University Hospital, Basel, Switzerland · Updated on 2026-03-27
20
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates whether MDMA may have a pain-reducing effect. The effect of MDMA is compared with a placebo (a substance with no active effect). In the study, moderate pain will be artificially created in healthy participants using repeated small electrical pulses applied under the skin. At the same time, participants will take MDMA or a placebo by mouth. This allows researchers to compare how MDMA affects the artificially created pain. A total of 20 healthy volunteers will take part in this study.
CONDITIONS
Official Title
Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years old
- Sufficient understanding of the German language
- Understanding of procedures and risks associated with the study
- Willing to adhere to the protocol and sign the consent form
- Willing to refrain from illicit psychoactive substances during the study
- Willing not to operate heavy machinery for 48 hours after the study session
- Willing to use effective birth control throughout study participation
- Body mass index between 18 and 34.9 kg/m2
You will not qualify if you...
- Relevant chronic or acute medical condition
- Any implanted medical devices such as pacemakers, neurostimulators, or metal prostheses
- Current or previous major psychiatric disorder including bipolar disorder or schizophrenia, current depression or anxiety disorder
- Psychotic disorder or bipolar disorder in first-degree relatives
- Hypertension with systolic blood pressure over 140 mmHg or diastolic over 90 mmHg
- Hypotension with systolic blood pressure under 85 mmHg
- Lifetime use of MDMA on more than 20 occasions or any use within the previous two months
- Pregnancy or current breastfeeding
- Participation in another clinical trial currently or within the last 30 days
- Use of medication that may interfere with the effects of the study medication
- Tobacco smoking of more than 10 cigarettes per day
- Consumption of alcoholic beverages exceeding 15 drinks per week
AI-Screening
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Trial Site Locations
Total: 1 location
1
Clinical Pharmacology & Toxicology, University Hospital Basel
Basel, Switzerland, 4056
Actively Recruiting
Research Team
S
Severin B Vogt, Dr. med.
CONTACT
M
Matthias E Liechti, Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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