Actively Recruiting
Acute and Chronic Effects of Obesity
Led by Concordia University, Montreal · Updated on 2026-04-07
150
Participants Needed
2
Research Sites
222 weeks
Total Duration
On this page
Sponsors
C
Concordia University, Montreal
Lead Sponsor
M
Montreal Children's Hospital of the MUHC
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to understand if there are differences in the fat, muscle and metabolism of individuals who developed obesity during childhood versus those who developed obesity in adulthood. We will do this by having recruited participants undergo subcutaneous adipose tissue biopsies in the abdomen and thigh, a muscle biopsy in the thigh, collect blood and urine samples, a DEXA scan and 3 submaximal exercise tests. participants will also have their resting energy expenditure measured through indirect calorimetry to tailor a targeted weight loss protocol through caloric restriction and cardiovascular exercise (3 times a week). After 10% of weight loss is completed, study participants will repeat all tests during a 2 week weight stabilization period. At 12 weeks into the intervention, indirect calorimetry, DEXA scan and blood tests will be repeated.
CONDITIONS
Official Title
Acute and Chronic Effects of Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Sedentary or untrained males and pre-menopausal females aged 25 to 40 years
- Body mass index (BMI) between 30.0 and 39.9 kg/m2
- Provide medical record or photographic evidence of weight at childhood (around age 10 to 17 years old)
- BMI between 40.0 and 41.9 may be included if height is very short, as BMI may not properly define obesity type
- Weight stable for at least 2 months
- Completion of DEXA scan for accurate obesity level assessment
You will not qualify if you...
- Pregnant or planning to become pregnant
- Breastfeeding
- Currently using nicotine-containing products (e.g., cigarettes, chewing tobacco, nicotine gum)
- Taking certain antidepressants or antihypertensive medications that affect weight
- History of surgery affecting weight or immune function (e.g., gastric bypass, magnetic implants)
- Conditions affecting immune function or study outcomes (e.g., iron deficiency anemia)
- Diseases such as diabetes, cancer, inflammatory bowel disease, history of eating disorders, or mental illness
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Concordia University PERFORM Centre
Montreal, Quebec, Canada, H4B 1R6
Actively Recruiting
2
Concordia University PERFORM Centre
Montreal, Quebec, Canada
Actively Recruiting
Research Team
S
Sylvia Santosa, R.D, Ph.D
CONTACT
K
Kayla Toledano, Ph.D Student
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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