Actively Recruiting
Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound
Led by Università degli Studi del Piemonte Orientale Amedeo Avogadro · Updated on 2026-01-08
200
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute dyspnea is a common reason for emergency department (ED) admission and is frequently caused by acute heart failure with pulmonary edema. Rapid differentiation between cardiogenic and non-cardiogenic causes of dyspnea is essential to guide early treatment and risk stratification. However, no single gold standard exists for the assessment of venous congestion in the acute setting. This prospective observational study aims to evaluate the diagnostic accuracy of respiratory variation in inferior vena cava (IVC) diameter measured by point-of-care ultrasound (POCUS) in identifying acute pulmonary edema in patients presenting to the ED with acute respiratory failure. In addition, the study investigates whether integration of IVC ultrasound with lung ultrasound, bedside cardiac ultrasound, and selected clinical and laboratory variables - such as hemoglobin and plasma protein changes - improves diagnostic performance and prognostic stratification.
CONDITIONS
Official Title
Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged �3e=18 years
- Presenting to the emergency department with acute dyspnea and acute respiratory failure defined by at least one of the following: PaO2 < 60 mmHg on room air, oxygen saturation (SpO2) < 90% on room air, or PaO2/FiO2 ratio < 300
- Able to provide written informed consent or eligible for deferred consent according to local regulations
- Undergoing standard diagnostic evaluation including laboratory tests and chest imaging as part of routine care
You will not qualify if you...
- Refusal to provide informed consent or consent by legal representative when applicable
- Inadequate ultrasound window or technically insufficient ultrasound assessment
- Acute respiratory failure due to chest trauma
- Cardiac arrest at presentation or during emergency department stabilization
- Requirement for invasive mechanical ventilation during initial emergency department stabilization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Azienda Ospedaliero-Universitaria Maggiore della Carità
Novara, Italy, 28100
Actively Recruiting
Research Team
F
Francesco Gavelli, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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