What is apple cider vinegar studying for obesity-related oxidative stress?

This study is evaluating whether a single dose of apple cider vinegar before a meal affects oxidative stress in adults with obesity by measuring changes in plasma malondialdehyde levels after eating. The research is led by Indonesia University to explore simple dietary strategies that may reduce oxidative stress.

Who may be eligible for this obesity clinical trial?

Adults aged 19 to 59 years with obesity (BMI of 25.0 kg/m² or higher), in good health without chronic diseases, can participate. Both genders are eligible, but pregnant, breastfeeding, or menopausal women, those consuming alcohol, or those intolerant to apple cider vinegar cannot join. Please review eligibility criteria for more details.

Is there any cost to participate in this obesity clinical trial?

Study-related care, including the apple cider vinegar and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered. Participants can plan accordingly for any related travel costs.

Actively Recruiting

Phase Not Applicable

Age: 19Years - 59Years

All Genders

Healthy Volunteers

ID07414875

Acute Effect of Apple Cider Vinegar Consumption on Postprandial Plasma Malondialdehyde Level in Adults With Obesity

Led by Indonesia University · Updated on 2026-02-24

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This research investigates whether consuming apple cider vinegar affects post-meal oxidative stress in adults with obesity. The study focuses on changes in plasma malondialdehyde MDA, a marker of lipid peroxidation linked to oxidative damage and cardiometabolic risk. Researchers aim to provide evidence on the acute effects of apple cider vinegar on postprandial lipid peroxidation, which has not been extensively studied before. Participants will be randomly assigned to one of two groups an intervention group that receives a single dose of 15 mL apple cider vinegar diluted in 250 mL water before a standardized meal, and a control group that receives only 250 mL water. After beverage consumption, participants eat a standardized meal. The study includes a one-week run-in period with diet education and lifestyle restrictions to reduce factors affecting oxidative stress. During the study visit, participants fast overnight and provide blood samples before and three hours after the meal to measure plasma MDA levels. The primary outcome is the change in postprandial plasma MDA concentration. Compliance with meal and beverage intake is monitored, and non-compliant participants will be excluded from per-protocol analysis. The total study duration includes pre-intervention education and a single intervention visit.

CONDITIONS

Brief Title

Acute Effect of Apple Cider Vinegar on Postprandial Plasma Malondialdehyde in Adult With Obesity

Who Can Participate

Age: 19Years - 59Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Adults aged 19 to 59 years
Obesity defined as BMI of 25.0 kg/m² or higher according to Asia-Pacific classification
In good general health
No diagnosed chronic diseases such as diabetes, heart disease, kidney disease, cancer, hepatitis, or chronic infections
Willing to participate in the entire study and provide informed consent

You will not qualify if you...

Pregnant, breastfeeding, or menopausal women
Alcohol consumption
Intolerance to apple cider vinegar or fermented products

Research Team

Ika Handayani, MD

Ika Handayani

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