Actively Recruiting
Acute Effect of Apple Cider Vinegar Consumption on Postprandial Plasma Malondialdehyde Level in Adults With Obesity
Led by Indonesia University · Updated on 2026-02-24
46
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research investigates whether consuming apple cider vinegar affects post-meal oxidative stress in adults with obesity. The study focuses on changes in plasma malondialdehyde (MDA), a marker of lipid peroxidation linked to oxidative damage and cardiometabolic risk. Researchers aim to provide evidence on the acute effects of apple cider vinegar on postprandial lipid peroxidation, which has not been extensively studied before. Participants will be randomly assigned to one of two groups: an intervention group that receives a single dose of 15 mL apple cider vinegar diluted in 250 mL water before a standardized meal, and a control group that receives only 250 mL water. After beverage consumption, participants eat a standardized meal. The study includes a one-week run-in period with diet education and lifestyle restrictions to reduce factors affecting oxidative stress. During the study visit, participants fast overnight and provide blood samples before and three hours after the meal to measure plasma MDA levels. The primary outcome is the change in postprandial plasma MDA concentration. Compliance with meal and beverage intake is monitored, and non-compliant participants will be excluded from per-protocol analysis. The total study duration includes pre-intervention education and a single intervention visit.
CONDITIONS
Brief Title
Acute Effect of Apple Cider Vinegar on Postprandial Plasma Malondialdehyde in Adult With Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 19 to 59 years
- Obesity defined as BMI of 25.0 kg/m² or higher according to Asia-Pacific classification
- In good general health
- No diagnosed chronic diseases such as diabetes, heart disease, kidney disease, cancer, hepatitis, or chronic infections
- Willing to participate in the entire study and provide informed consent
You will not qualify if you...
- Pregnant, breastfeeding, or menopausal women
- Alcohol consumption
- Intolerance to apple cider vinegar or fermented products
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 week
Participants follow a balanced diet and avoid antioxidant supplements and strenuous physical activity for one week before the intervention.
Duration - Study visit day
Participants consume a single dose of apple cider vinegar or water before a standardized meal to assess post-meal changes in plasma malondialdehyde levels.
1 visit (in-person) including baseline fasting and 3-hour post-meal blood samples
Trial Site Locations
Total: 1 location
1
Ministry of Youth and Sports of the Republic of Indonesia (KEMENPORA RI)
Jakarta, Indonesia
Actively Recruiting
Research Team
I
Ika Handayani, MD
I
Ika Handayani
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here