Study of How Cold Exposure Affects the Heart and Blood Vessels in Healthy Young Adults in Shanghai

What this Trial Is About

Researchers are conducting a randomized controlled crossover study to explore how brief exposure to low temperature affects the cardiovascular system and its underlying mechanisms. This study involves about 40 healthy young adults living in Shanghai, China, aiming to understand acute cardiovascular responses to cold exposure compared to moderate temperature conditions. Participants will experience two separate exposure sessions in a controlled chamber one at low temperature 150C and one at moderate temperature 220C, each lasting about 2 hours. During these sessions, participants will rest quietly. The study design allows comparison of cardiovascular effects between the two temperature settings. Throughout the study, participants will undergo health examinations before, during, and after exposure sessions. These include blood pressure measurements and continuous heart monitoring via Holter monitors worn for 24 hours starting at 100 P.M. on the day of exposure. Blood and urine samples will also be collected. Questionnaires about symptoms and skin temperature monitoring during exposure will provide additional data. The study evaluates detailed heart rate variability measures and blood pressure changes to understand cold exposure impacts.

Acute Effects of Cold Exposure on Cardiovascular System