Using Focused Ultrasound to Reduce Seizures in Adults with Status Epilepticus Treatment Study in ICU Patients with Non-Convulsive or Focal Motor Seizures

What this Trial Is About

Researchers are evaluating the use of Pulsed Low-Intensity Focused Ultrasound PLIFU to reduce or suppress seizure activity in adults experiencing non-convulsive or focal motor status epilepticus SE who have not responded to standard treatments. The study focuses on brain regions that generate or control seizures, aiming to assess the effects of this non-invasive brain stimulation in a hospital setting. Participants will receive up to two sessions of PLIFU treatment in the Intensive Care Unit. Each session lasts 10 minutes and uses a custom device that delivers ultrasound to specific brain areas without damaging tissue. Treatments will be given after anti-seizure medications have been administered, and the ultrasound is applied using safe, non-thermal settings. During the study, participants will be monitored continuously with surface EEG to measure epileptic brain activity before, during, and after PLIFU treatment. Researchers will observe changes in seizure activity and follow participants throughout their hospital stay. The main outcome is the change in epileptiform activity measured by EEG at baseline and 10 minutes after treatment. The study aims to gather preliminary data to support future research.

Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients