What is Low-Level Laser Therapy (LLLT) studying for pain?

Low-Level Laser Therapy (LLLT) is being studied to see if a single session can immediately change pain threshold and pain tolerance in healthy adults. The research aims to understand how LLLT may affect acute pain perception compared to a sham treatment. This study is sponsored by the European University of Lefke.

Who may be eligible for this pain clinical trial?

Adults aged 18 to 35 who are healthy and free from chronic or acute pain may be eligible. All genders can participate. People who are pregnant, have neurological disorders, or recent use of pain medications may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this pain clinical trial?

Study-related care, including the laser procedure and all trial visits, is provided at no cost. However, personal travel and related expenses may vary and are not guaranteed to be covered. Participants should plan accordingly.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 35Years

All Genders

Healthy Volunteers

ID07422272

Examining the Immediate Effects of Low-Level Laser Therapy on Pain Threshold and Tolerance in Healthy Adults A Randomized Controlled Trial

Led by European University of Lefke · Updated on 2026-02-19

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Pain is described as an unpleasant sensory and emotional experience linked to actual or potential tissue damage. This research evaluates whether a single session of Low-Level Laser Therapy LLLT, a safe and noninvasive treatment with pain-relief and anti-inflammatory effects, can produce immediate changes in pain threshold and pain tolerance in healthy adults. This study focuses on acute nociceptive pain, common in musculoskeletal conditions, and aims to understand LLLTs immediate impact compared to a sham treatment. Participants will be randomly assigned to receive either active LLLT or a sham laser procedure. The active treatment uses a 904 nm wavelength laser applied to three points near the medial epicondyle for a total of 6 minutes, delivering a set energy dose. The sham group undergoes the same procedure without actual laser emission to control for placebo effects. Both groups and the researcher wear safety eyewear during the process. During the study, researchers will measure electrical pain threshold and pain tolerance before and immediately after the intervention. Participants are healthy adults aged 18 to 35 without chronic medical conditions or pain. The trial includes monitoring for safety and adherence to protocols. The total participation involves a single session assessing immediate effects, with no long-term follow-up described.

CONDITIONS

Brief Title

Acute Effects of LLLT on Pain Threshold and Pain Tolerance

Who Can Participate

Age: 18Years - 35Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Age between 18 and 35 years
Healthy individuals without chronic medical conditions
Free from chronic or acute pain
All genders
Able to provide informed consent

You will not qualify if you...

Menstruation at the time of testing
Sensory deficits (failure to pass sharp-dull test)
Pregnancy
History of epilepsy
Presence of cardiovascular conditions (including pacemaker)
Acute hand injuries
Diagnosed neurological disorders
Use of analgesics or NSAIDs within the previous 48 hours
Contraindications to low-level laser therapy or electrical stimulation (e.g., light sensitivity, malignancy)

Research Team

Yara Mabrouk Houtar

Asst. Prof. Dr. Beraat Alptuğ Alptuğ

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