Effect of pulsing in low-level light therapy.
Javad T Hashmi, Ying-Ying Huang, Sulbha K Sharma...
https://pubmed.ncbi.nlm.nih.gov/20662021Actively Recruiting
Phase Not Applicable
Age: 18Years - 35Years
All Genders
Healthy Volunteers
ID07422272
Examining the Immediate Effects of Low-Level Laser Therapy on Pain Threshold and Tolerance in Healthy Adults: A Randomized Controlled Trial
Led by European University of Lefke · Updated on 2026-02-19
52
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Pain is described as an unpleasant sensory and emotional experience linked to actual or potential tissue damage. This research evaluates whether a single session of Low-Level Laser Therapy (LLLT), a safe and noninvasive treatment with pain-relief and anti-inflammatory effects, can produce immediate changes in pain threshold and pain tolerance in healthy adults. This study focuses on acute nociceptive pain, common in musculoskeletal conditions, and aims to understand LLLT's immediate impact compared to a sham treatment. Participants will be randomly assigned to receive either active LLLT or a sham laser procedure. The active treatment uses a 904 nm wavelength laser applied to three points near the medial epicondyle for a total of 6 minutes, delivering a set energy dose. The sham group undergoes the same procedure without actual laser emission to control for placebo effects. Both groups and the researcher wear safety eyewear during the process. During the study, researchers will measure electrical pain threshold and pain tolerance before and immediately after the intervention. Participants are healthy adults aged 18 to 35 without chronic medical conditions or pain. The trial includes monitoring for safety and adherence to protocols. The total participation involves a single session assessing immediate effects, with no long-term follow-up described.
CONDITIONS
Brief Title
Acute Effects of LLLT on Pain Threshold and Pain Tolerance
Who Can Participate
Age: 18Years - 35Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age between 18 and 35 years
- Healthy individuals without chronic medical conditions
- Free from chronic or acute pain
- All genders
- Able to provide informed consent
You will not qualify if you...
- Menstruation at the time of testing
- Sensory deficits (failure to pass sharp-dull test)
- Pregnancy
- History of epilepsy
- Presence of cardiovascular conditions (including pacemaker)
- Acute hand injuries
- Diagnosed neurological disorders
- Use of analgesics or NSAIDs within the previous 48 hours
- Contraindications to low-level laser therapy or electrical stimulation (e.g., light sensitivity, malignancy)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) to assess eligibility criteria including health status and absence of contraindications.
Implementation
Duration - Single session
Participants receive either active Low-Level Laser Therapy (LLLT) or a sham procedure applied to three standardized points near the medial epicondyle. The laser or sham is applied for a total of 6 minutes while wearing safety eyewear.
1 visit (in-person) for laser or sham application and immediate assessments.
Trial Site Locations
Total: 1 location
1
European University of Lefke
Lefka, Northern Cyprus, Cyprus, 99780
Actively Recruiting
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Research Team
Y
Yara Mabrouk Houtar
A
Asst. Prof. Dr. Beraat Alptuğ Alptuğ
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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Published Research Related To This Trial
Mechanisms and applications of the anti-inflammatory effects of photobiomodulation.
Michael R Hamblin
https://pubmed.ncbi.nlm.nih.gov/28748217A systematic review and network meta-analysis on the optimal wavelength of low-level light therapy (LLLT) in treating knee osteoarthritis symptoms.
Tianxiang Fan, Yang Li, Arnold Y L Wong...
https://pubmed.ncbi.nlm.nih.gov/39367994Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials.
Roberta T Chow, Mark I Johnson, Rodrigo A B Lopes-Martins...
https://pubmed.ncbi.nlm.nih.gov/19913903