Effects of Medium-Chain Triglyceride Formulations on Ketone, Lipid, and Glucose Levels in Healthy Adults A Randomized Crossover Study Comparing Natural and Synthetic MCTs and LCTs

What this Trial Is About

Researchers are evaluating how different medium-chain triglyceride MCT formulations affect beta-hydroxybutyrate levels, lipid metabolism, and glucose responses in healthy adults aged 18 to 40. The study aims to compare natural MCTs from coconut oil, synthetic MCTs, and long-chain triglycerides LCTs to understand their metabolic impacts and whether the form of consumption influences these effects. Participants consume five different lipid-based test products, including beverages and powders containing MCTs or LCTs, as well as an MCT biscuit. Each product is given in amounts adjusted to provide a lipid dose of 0.5 gkg body weight, with a randomized order and a washout period of at least 7 days between visits. Blood samples are collected for up to five hours after each intake to measure metabolic responses. During study visits, participants fast overnight before consuming each test product. Researchers monitor postprandial beta-hydroxybutyrate concentrations, glucose, triglycerides, fatty acid profiles, ghrelin levels, and subjective appetite using visual scales. The study assesses these responses over multiple visits, providing detailed insight into how different lipid formulations affect metabolism over time.

Acute Effects of MCT Formulations on Beta-Hydroxybutyrate Response, Lipid Profile, and Glucose Levels in Healthy Adults