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HIPAA Compliant
ISO 27001 Certified

Actively Recruiting

Phase Not Applicable
Age: 18Years - 40Years
MALE
Healthy Volunteers
ID07659301

Evaluating Breathing Oxygen in a Pressurized Chamber After Exercise to Improve Recovery and Performance in Healthy Male National-Level Cyclists Aged 18 to 40

Led by Université Catholique de Louvain · Updated on 2026-06-22

48

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

U

Université Catholique de Louvain

Lead Sponsor

M

Murdoch University

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are evaluating whether breathing oxygen in a pressurized chamber after intense cycling exercise can help competitive male cyclists recover better and improve their performance the next day. The study focuses on healthy male road cyclists aged 18 to 40 who compete at the national level in Belgium. Despite widespread use of hyperbaric oxygen therapy in sports recovery, clear scientific evidence of its benefits after a single session of strenuous endurance exercise is lacking. Participants complete a fatiguing cycling session then are randomly assigned to one of four groups receiving different oxygen levels during recovery. Two groups breathe pure oxygen at increased pressures of 2.5 or 1.4 atmospheres absolute inside a hyperbaric chamber. Another group breathes pure oxygen at normal atmospheric pressure, and the fourth receives a sham treatment that mimics the chamber environment without extra oxygen. The study is double-blind, so neither participants nor assessors know who receives which treatment. During the study, researchers measure next-day endurance performance by assessing the decline in time to exhaustion relative to baseline. Blood samples and physiological data are also collected to understand recovery mechanisms. Participation involves one hour of oxygen exposure after exercise, and the study spans about 18 months to capture these effects. Safety and recovery responses are closely monitored throughout.

CONDITIONS

Brief Title

Acute Effects of Post-Exercise Hyperoxia on Recovery in Cycling

Who Can Participate

Age: 18Years - 40Years
MALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Male road cyclists competing at national level in Belgium within the past 12 months
  • At least 2 consecutive years of structured cycling training at regional or national level
  • Cycling training volume of at least 8 hours per week over the last 10 weeks
  • Stable training load with no major changes due to injury or illness before inclusion
  • Measured maximal oxygen uptake (VO2max) of at least 60 ml/kg/min
Not Eligible

You will not qualify if you...

  • Significant cardiovascular, pulmonary, neurological, ENT, or metabolic diseases
  • Uncontrolled high blood pressure (systolic ≥ 180 mmHg or diastolic ≥ 110 mmHg)
  • Unstable heart disease or decompensated cardiomyopathy
  • Contraindications to hyperbaric exposure such as untreated pneumothorax or recent thoracic surgery
  • Neurological conditions including epilepsy, recent seizures, or oxygen-induced seizures
  • Ear, sinus, or Eustachian tube disorders preventing pressure equalization
  • Severe claustrophobia incompatible with chamber exposure

Research Team

T

Théo A MAHY, MSc

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