Actively Recruiting
Acute Effects of Stimulant Medication in College Students With ADHD
Led by University of Wyoming · Updated on 2024-06-10
40
Participants Needed
1
Research Sites
280 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators will examine the acute effects of stimulant medication on executive functioning. The rationale for the proposed study is to examine the efficacy of stimulants for college students with ADHD and help prevent stimulant misuse among college students without ADHD. The working hypothesis is that stimulants, compared to baseline and placebo conditions, will improve executive functioning for college students with ADHD but not for college students without ADHD. Improvements on executive functioning measures (e.g., CPT-IP, Spatial Span) will be examined through 2 (ADHD vs. non-ADHD) x 3 (Baseline, Placebo, Stimulant) repeated measures ANOVAs. Follow-up analyses will include paired comparisons. Expected outcomes are to confirm these hypotheses and demonstrate the need for further study of stimulants. If confirmed, the results will provide pilot data for a larger NIH grant proposal aimed at further examining the acute effects of stimulants (i.e., improved cognitive functioning with stimulants) and comparing them to the acute effects of physical exercise (i.e., improved cognitive functioning immediately after exercise). The investigators expect this outcome to have an important positive impact because it can help support stimulant medication as an effective treatment for college students with ADHD (DuPaul et al., 2012). Additionally, demonstration that stimulants do not improve executive functioning for college students without ADHD can be used to help prevent and discourage stimulant misuse and diversion on college campuses (Hartung et al., 2013).
CONDITIONS
Official Title
Acute Effects of Stimulant Medication in College Students With ADHD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be currently enrolled either full time or part time as an undergraduate in a 2-year or 4-year college
- Be between the ages of 18-29
- Be a native English speaker
- ADHD participants must have a prior diagnosis of ADHD and report five or more inattention symptoms on the DSM-5 Symptom Checklist
- Healthy participants must never have been diagnosed with ADHD and report 3 or fewer inattention symptoms and 3 or fewer hyperactivity/impulsivity symptoms on the DSM-5 Symptom Checklist
- Healthy participants must be age and sex matched with ADHD group participants
You will not qualify if you...
- Not meeting all inclusion criteria
- Having any acute or uncontrolled disease such as cardiovascular, pulmonary, neurological, endocrine, musculoskeletal, or immunological conditions
- Being non-ambulatory or needing walking aids
- Chronic asthma or respiratory conditions requiring inhaler use during exercise
- Uncontrolled or current syncope (fainting) or postural hypotension
- History of stroke, aneurysm, or transient ischemic attack (TIA)
- Restrictions on exercise or physical activity by a healthcare provider
- Pregnancy, trying to become pregnant, or breastfeeding
- Current use of psychotropic drugs like SSRIs, SNRIs, or sedatives
- History of seizure disorder, high blood pressure, glaucoma, gastrointestinal hypermotility, diabetes, hypoglycemia, heart disease, or thyroid problems
- Diagnosis of bipolar disorder, psychotic disorder, sleep disorder, eating disorder, or severe substance use disorder
- Past year diagnosis of major depressive disorder, panic disorder, generalized anxiety disorder, or any substance use disorder
- Past treatment for substance use or unwillingness to abstain from illicit or addictive drugs and marijuana during the study
- Non-prescription stimulant use for non-ADHD participants
- Current prescribed stimulant use for ADHD participants unless willing to abstain the day before and day of visits
- Current use of non-stimulant ADHD medications
- Use of prescription medications that may interact negatively with Adderall
- High caffeine consumption exceeding 600mg daily
- Use of over-the-counter substances that could interact with Adderall unless abstained from 12 hours prior
- Current nicotine use of 5 or more cigarettes per day or daily vaping
- History of concussion within the past 6 months, multiple concussions, or traumatic brain injury
- Unwillingness to take stimulant medication or placebo during the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Wyoming
Laramie, Wyoming, United States, 82071
Actively Recruiting
Research Team
C
Cynthia M Hartung, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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