Actively Recruiting
Acute Effects of Transcutaneous Electrical Nerve Stimulation at Acupoints on Nociceptive Transmission: A Mechanism Study Using Pain-Related Evoked Potentials
Led by China Medical University Hospital · Updated on 2025-12-05
35
Participants Needed
1
Research Sites
31 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation (TENS) applied to acupoints can modulate pain transmission and cortical processing in healthy adult volunteers. The main questions it aims to answer are: * Does TENS at Zhongzhu (SJ3) and Hegu (LI4) change pain-related evoked potentials (PREPs)? * Does acupoint electrical stimulation alter nociceptive pathways reflected by PREP waveform modulation? Researchers will compare PREPs recorded before and after TENS at the two acupoints to see if TENS produces measurable effects on cortical nociceptive responses. Participants will receive low-frequency TENS applied to Zhongzhu (SJ3) and Hegu (LI4), and undergo PREP assessments before and after the intervention to measure cortical responses to standardized noxious stimuli.
CONDITIONS
Official Title
Acute Effects of Transcutaneous Electrical Nerve Stimulation at Acupoints on Nociceptive Transmission: A Mechanism Study Using Pain-Related Evoked Potentials
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults aged 20 years or older
- No chronic medical conditions
- No history of drug allergies or skin disorders
- Not currently using medications that may affect study results
- Maintain a regular daily routine
- No history of substance or medication abuse
You will not qualify if you...
- History of malignant tumors
- History of hand disorders
- Presence of an implanted cardiac pacemaker
- Pregnancy
- Epilepsy
- Any other condition that may interfere with study procedures
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Physical Therapy of China Medical University
Taichung, Beitun, Taiwan, Taiwan, 406040
Actively Recruiting
Research Team
Y
Yueh-Ling Hsieh
CONTACT
Y
Yung-Yu Hsu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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