Actively Recruiting
Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis
Led by AdventHealth Translational Research Institute · Updated on 2026-04-17
12
Participants Needed
1
Research Sites
48 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by the liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).
CONDITIONS
Official Title
Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form provided
- Willing to comply with all study procedures and available for the study duration
- Male or pre-menopausal female, aged 25 to 55 years
- For Type 2 diabetes group: BMI between 25 and 45 kg/m2
- Sedentary lifestyle (exercise 1 day or less per week)
- Diagnosed Type 2 diabetes with HbA1c 7.5% or higher
- Liver fat 5.6% or higher based on MRI
- Weight stable within ±2 kg for the last 3 months
- For healthy control group: BMI between 18.5 and 27.5 kg/m2
- Normal liver fat (FibroScan CAP <249 dB/m and MRI liver fat <5.6%)
- Weight stable within ±2 kg for the last 3 months
- Active lifestyle (exercise 3 or more days per week)
You will not qualify if you...
- Currently taking insulin, injectable incretin mimetics, or thiazolidinediones
- Recent change in glucose-lowering medications within the last 3 months
- Unable to stop medications affecting glucose metabolism for specific visits
- Resting blood pressure 160/100 mm Hg or higher
- Triglycerides 500 mg/dL or higher
- Any renal, cardiac, liver, lung, or neurological disease compromising safety or exercise ability
- Significant or unstable medical conditions like coronary heart disease or chronic organ failure
- Clinically significant ECG abnormalities contra-indicating exercise testing
- Active cancer except basal cell carcinoma
- Pregnancy in the last 6 months, lactating, or planning pregnancy soon
- Post- or peri-menopausal women or history of hysterectomy
- Use of drugs affecting energy metabolism or body weight
- Untreated or unstable thyroid disorders
- Current blood thinners or anti-platelet therapy that cannot be stopped
- Recent major surgery or bariatric surgery
- Abnormal blood counts or recent blood transfusion/donation
- Current smoking or recent tobacco use
- Current drug or alcohol abuse or positive toxicology
- Excessive alcohol consumption or history of binge drinking
- Metal implants affecting MRI safety
- Physical inability to perform study exercise or undergo MRI
- Claustrophobia or intolerance to MRI
- Psychotic or psychiatric conditions affecting study adherence
- Chronic infections requiring treatment or active hepatitis/HIV
- Unable or unwilling to communicate or provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
AdventHealth Translational Research Institute
Orlando, Florida, United States, 32804
Actively Recruiting
Research Team
R
Recruitment Department
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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