Study of How Acute Exercise Affects Liver Glucose Production in Adults With and Without Type 2 Diabetes and Fatty Liver Disease

What this Trial Is About

This research aims to understand how exercise affects the livers production of glucose in adults aged 25 to 55 years, both with and without Type 2 diabetes T2D and fatty liver disease hepatic steatosis. It compares glucose production between healthy individuals and those with T2D and elevated liver fat, seeking insights that may help improve blood sugar control and treatment of fatty liver conditions. Participants are divided into two groups lean, healthy controls and individuals with T2D and hepatic steatosis. The study includes assessments such as magnetic resonance imaging MRI to measure liver fat, cycling exercise tests to evaluate maximal fitness, and DEXA scans to analyze body composition. These procedures help researchers observe physiological differences and responses related to glucose production. During the study, participants will undergo various tests including liver fat measurement by MRI, fitness evaluation using a cycle ergometer, and body composition analysis by DEXA. Researchers will measure endogenous glucose production on Day 14 to assess changes. Participants must follow study procedures and remain available throughout the study, which runs until December 2028. The study also monitors safety and adherence to protocols during this time.

Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis