Actively Recruiting
Acute Heart Failure - COngestion Discharge Evaluation Evaluating Congestion at Hospital Discharge for Acute Heart Failure
Led by Central Hospital, Nancy, France · Updated on 2023-06-05
110
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute heart failure (AHF) is a serious health issue with a high risk of death or hospital readmission within three months after discharge. This risk increases when fluid buildup in the body is not adequately reduced by the end of the hospital stay, as measured by clinical scores, blood tests, or ultrasound scans. Although implantable devices can help guide treatment to reduce lung congestion, current methods to assess congestion lack standardization, making treatment adjustments mostly trial and error. This trial aims to find the best way to evaluate congestion in patients recovering from acute heart failure. Patients hospitalized for acute heart failure will receive several evaluations before discharge, including clinical exams focused on congestion and various Doppler ultrasounds of the heart, lungs, abdomen, neck veins, and kidneys, along with liver elastography. Blood samples will be taken for biological tests and storage. After leaving the hospital, participants will have telephone follow-ups at 3, 12, and 24 months. Quality of life will be assessed using the Kansas City Cardiomyopathy Questionnaire at discharge and during follow-up visits. Throughout the study, researchers will monitor outcomes such as death rates, hospital readmissions, and intravenous diuretic treatments at 3, 12, and 24 months after discharge. They will also assess heart function, kidney function, plasma volume, liver health, and patient quality of life. The study involves detailed clinical, imaging, and laboratory assessments to understand congestion better and how it relates to patient outcomes over a two-year period.
CONDITIONS
Brief Title
Acute Heart Failure - COngestion Discharge Evaluation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients hospitalized for acute heart failure
- Patients considered clinically ready to be discharged from hospital for acute heart failure
- Age 18 years or older
- Patients who have received complete information about the study and signed informed consent
- Patients affiliated with or beneficiaries of a social security scheme
You will not qualify if you...
- Life expectancy of 3 months or less due to comorbid conditions
- Patients on dialysis (peritoneal or hemodialysis) or with glomerular filtration rate below 15 ml/min/m2 at inclusion
- History of lobectomy or pneumonectomy lung surgery
- Severe pulmonary or pleural diseases preventing reliable lung ultrasound imaging, such as severe emphysema, chronic pleurisy, or pulmonary fibrosis
- Pregnant women, women in labor, or breastfeeding mothers
- Adults under legal protection measures (guardianship, curatorship, or safeguard of justice)
- Adults unable to give consent
- Individuals deprived of liberty by judicial or administrative decision
- Persons receiving psychiatric care under specific public health code articles
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to hospital discharge
Participants undergo clinical examinations focusing on congestion, including cardiac, pulmonary, peritoneal, jugular, and renal Doppler ultrasounds, liver elastography, and blood sample collection before hospital discharge.
1 visit (in-person) before discharge
Duration - 24 months after discharge
Participants receive telephone follow-ups and complete quality of life questionnaires at 3, 12, and 24 months after hospital discharge to monitor their health status.
3 telephone follow-up calls at 3, 12, and 24 months
Trial Site Locations
Total: 1 location
1
CHRU de Nancy
Vandœuvre-lès-Nancy, France, 54500
Actively Recruiting
Research Team
N
Nicolas GIRERD, MD,PhD
S
Sanae BOUALI, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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