Actively Recruiting
Acute Myeloid Leukemia At Initial Diagnosis and/or Relapse in Children, Teenagers and Young Adults: Molecular Profiling, Multidrug Testing and MSC Interaction Studies
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2024-06-26
500
Participants Needed
28
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pediatric acute myeloid leukemias are disease with poor prognosis (overall survival of 60-75%) and high relapse rate of 35-45% require further understanding of the underlying biological mechanisms. The main objective of this study is to establish a biological collection to evaluate the genomic profiling of leukemic cells from primary blasts at diagnosis and/or relapse to improve identification of the main genetic hits involved in resistance and could predict a high risk of relapse. Other objectives include the study of bone marrow mesenchymal stem cells and ex vivo drug testing.
CONDITIONS
Official Title
Acute Myeloid Leukemia At Initial Diagnosis and/or Relapse in Children, Teenagers and Young Adults: Molecular Profiling, Multidrug Testing and MSC Interaction Studies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 0 to 25 years
- Newly diagnosed de novo or secondary acute myeloid leukemia (AML)
- Relapsed or refractory AML
- Genetic predisposition to develop AML
- No hematological malignancy or AML genetic predisposition syndrome but undergoing bone marrow aspirate as part of standard care
- Signed informed consent from parents if under 18, or from patient if 18 or older
You will not qualify if you...
- Refusal to participate
- Chronic myeloid leukemia (CML)
- Lack of French health insurance
- Under legal protection (tutelle, curatelle, or sauvegarde de justice)
- Pregnancy or breastfeeding
AI-Screening
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Trial Site Locations
Total: 28 locations
1
CHU Amiens Picardie site Sud
Amiens, France
Actively Recruiting
2
CHU Angers
Angers, France
Actively Recruiting
3
Hopital Minjoz
Besançon, France
Actively Recruiting
4
CHU Pellegrin
Bordeaux, France
Actively Recruiting
5
CHRU Morvan
Brest, France
Actively Recruiting
6
CHU Caen
Caen, France
Actively Recruiting
7
CHU Estaing
Clermont-Ferrand, France
Actively Recruiting
8
CHU Francois Mitterand
Dijon, France
Actively Recruiting
9
CHU Grenoble
Grenoble, France
Actively Recruiting
10
CHU de la Réunion
La Réunion, France
Actively Recruiting
11
Hopital Jeanne de Flandre - CHRU
Lille, France
Actively Recruiting
12
CHU Limoges
Limoges, France
Actively Recruiting
13
HCL Lyon
Lyon, France
Actively Recruiting
14
Hôpital d'Enfants de la Timone
Marseille, France
Actively Recruiting
15
CHU Montpellier
Montpellier, France
Actively Recruiting
16
CHRU Nancy- Hopitaux de Brabois
Nancy, France
Actively Recruiting
17
CHU Nantes
Nantes, France
Actively Recruiting
18
CHU Nice
Nice, France
Actively Recruiting
19
Hopital Robert Debré
Paris, France
Actively Recruiting
20
Hopital Trousseau
Paris, France
Actively Recruiting
21
CHU Poitiers
Poitiers, France
Actively Recruiting
22
Hopital Américain
Reims, France
Actively Recruiting
23
CHU Hopital Sud
Rennes, France
Actively Recruiting
24
CHU Rouen
Rouen, France
Actively Recruiting
25
CHU Saint Etienne
Saint-Etienne, France
Actively Recruiting
26
Hopital Hautepierre
Strasbourg, France
Actively Recruiting
27
CHU Toulouse
Toulouse, France
Actively Recruiting
28
CHRU Tours
Tours, France
Actively Recruiting
Research Team
A
Arnaud PETIT, Pr
CONTACT
J
Jérôme Lambert, Pr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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