Actively Recruiting
A Master Protocol to Evaluate the Safety, Tolerability, and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis
Led by argenx · Updated on 2026-06-03
70
Participants Needed
15
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the safety and effectiveness of different drug regimens in people with myasthenia gravis, a condition affecting muscle strength. The study aims to find the best treatment options that reduce side effects and improve quality of life. It uses a master protocol to test multiple treatments in separate groups called intervention-specific appendixes (ISAs). The platform study includes a common screening period and ISA-specific screening, treatment, and safety follow-up periods. One ISA focuses on adding empasiprubart intravenous infusion to efgartigimod intravenous infusion for participants with generalized myasthenia gravis who have a partial response to efgartigimod. Each ISA has its own schedule and duration. Participants will undergo screening, receive assigned treatments, and be monitored for safety and treatment effects over up to approximately seven years, depending on the ISA. Researchers will assess safety, tolerability, and how well the treatments work for different myasthenia gravis subtypes during the study periods.
CONDITIONS
Brief Title
ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Is at least 18 years of age and the local legal age of consent for clinical studies
- Has been diagnosed with myasthenia gravis with consistent clinical features per investigator's judgment
- If receiving MG therapy (nonsteroidal immunosuppressive drugs, corticosteroids, or acetylcholinesterase inhibitors), dosage should be stable before screening
You will not qualify if you...
- Has known autoimmune disease or other medical condition that interferes with MG symptom assessment or increases risk
- Is Myasthenia Gravis Foundation of America Class V
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to approximately 7 years (varies by regimen)
Participants receive intravenous infusions of study regimens, including monotherapy or add-on therapy to backbone therapy, to evaluate safety, tolerability, and efficacy in myasthenia gravis subtypes.
Visit schedule varies per regimen and is specified in intervention-specific appendixes
Duration - Variable duration as specified in intervention-specific appendixes
Participants are monitored for safety and tolerability after the treatment period ends.
Visit schedule varies according to safety follow-up requirements
Trial Site Locations
Total: 15 locations
1
Profound Research LLC - Carlsbad
Carlsbad, California, United States, 92011
Actively Recruiting
2
Visionary Investigators Network
Miami, Florida, United States, 33133
Actively Recruiting
3
University of South Florida
Tampa, Florida, United States, 33620
Actively Recruiting
4
Erlanger Health System
Columbia, Maryland, United States, 21044
Actively Recruiting
5
Dent Neurologic Institute - Amherst
Amherst, New York, United States, 14226
Actively Recruiting
6
Ohio State Martha Morehouse Outpatient Care
Columbus, Ohio, United States, 43221-3502
Actively Recruiting
7
Erlanger Health System
Chattanooga, Tennessee, United States, 37403-2136
Actively Recruiting
8
National Neuromuscular Research Institute
Austin, Texas, United States, 78759
Actively Recruiting
9
University of Texas- San Antonio - Health Science Center - PPDS
San Antonio, Texas, United States, 78229
Actively Recruiting
10
UZ Leuven - PPDS
Leuven, Belgium, 3000
Actively Recruiting
11
ASST Papa Giovanni XXIII - Ospedale Papa Giovanni XXIII
Bergamo, Lombardy, Italy, 24127
Actively Recruiting
12
MICS Centrum Medyczne Bydgoszcz
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-065
Actively Recruiting
13
Krakowska Akademia Neurologii Sp. z o.o.
Krakow, Lesser Poland Voivodeship, Poland, 31-505
Actively Recruiting
14
Centrum Medyczne Neurologia Slaska
Katowice, Silesian Voivodeship, Poland, 40-689
Actively Recruiting
15
Hospital Regional Universitario de Malaga - Hospital General
Málaga, Malaga, Spain, 340120
Actively Recruiting
Research Team
S
Sabine Coppieters, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here